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Molecular Human Reproduction Vol. 1, NUMBER 8 pp. 381-386, 1995
© European Society of Human Reproduction and Embryology 1995

research-article

Effects of epidermal growth factor, transforming growth factor {alpha} and androstenedione on follicular growth and aromatization in culture

Ghanim Almahbobi1, Anjalee Nagodavithane and Alan O. Trounson

Laboratories of Human and Animal Reproductive Biology, Institute of Reproduction and Development Monash University, Clayton, Victoria 3168, Australia

To whom correspondence should be addressed at: 1To whom correspondence should be addressed

The effects of epidermal growth factor (EGF), transforming growth factor alpha (TGF{alpha}) and androstenedione on follicular growth and oestradiol production were studied in cultured mouse preantral follicles. Cultured follicles in the control group showed growth and steroidogenic capacities up to the antral follicle stage at day 4 of culture. However, many of these follicles failed to resume their growth during the culture. Increasing concentrations of EGF and TGF{alpha} decreased the number of follicles reaching the large antral stage at day 4 of culture. All treatments with EGF, TGF{alpha} and androstenedione caused significant inhibitions in both follicular growth and oestradiol production, regardless of the dose used (1–20 ng/ml). Moreover, no synergistic effect between androstenedione and either of the two growth factors was observed. These results suggest that EGF, TGF{alpha} and/or androstenedione may play important roles in the modulation of gonadotrophin-controlled ovarian function. The effects observed in this study suggest that the aberration in the regulation of these growth factors may result in the creation and maintenance of certain ovarian disorders, such as the polycystic ovarian disease.

EGF/follicle/mouse/PCO/TGF{alpha}


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