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Mol. Hum. Reprod. Advance Access originally published online on August 20, 2004
Molecular Human Reproduction 2004 10(10):735-742; doi:10.1093/molehr/gah100
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Molecular Human Reproduction vol. 10 no. 10 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours

Takanobu Kanamori1,2, Kenji Takakura1, Masaki Mandai1, Masatoshi Kariya1, Ken Fukuhara1,2, Masakiyo Sakaguchi3, Nam-ho Huh3, Kaoru Saito4, Toshiharu Sakurai2, Jun Fujita2 and Shingo Fujii1,5

1Department of Gynecology and Obstetrics and 2Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, 606-8507, 3Department of Cell Biology, Okayama University, Graduate School of Medicine and Dentistry, Okayama, 700-8558 and 4Department of Obstetrics and Gynecology, School of Medicine, St Marianna University, Kawasaki, 216-8511, Japan

5 To whom correspondence should be addressed at: Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, 54, Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan. Email: sfu{at}kuhp.kyoto-u.ac.jp

S100 proteins belong to the EF-hand Ca2+ -binding protein family and regulate a variety of cellular processes via interaction with different target proteins. Several diseases, including cancer and melanoma, are related to the abnormal expression of S100 proteins, which are expressed in cell- and tissue-specific manners. We investigated the expression of S100 family members in human uterine smooth muscle tumours. Expression of six members of the S100 protein family: S100A1, A4, A6, A7, A10 and A11, was found in human uterine leiomyoma and myometrium tissue, but expression of other members was not detected by RT–PCR. Real-time PCR showed that S100A11 expression was significantly increased in leiomyoma compared with myometrium. Suppression of S100A11 by small interfering RNA (siRNA) led to apoptosis, and the overexpression of S100A11 inhibited apoptosis in human uterine smooth muscle tumour cells. These findings suggest that S100A11 has an anti-apoptotic function and is related to the process of growth of human uterine leiomyoma.


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