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Mol. Hum. Reprod. Advance Access originally published online on September 24, 2004
Molecular Human Reproduction 2004 10(11):835-838; doi:10.1093/molehr/gah111
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Molecular Human Reproduction vol. 10 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Chromosome aneuploidy in the spermatozoa of two men with globozoospermia

F. Morel1,2,*, N. Douet-Guilbert1,2,*, A. Moerman3, B. Duban4, C. Marchetti5, B. Delobel4, M.-J. Le Bris2, V. Amice2 and M. De Braekeleer1,2,6

1Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, Brest, 2Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest, 3Service de Génétique Clinique, CHRU, Lille, 4Centre de Génétique Chromosomique, Hôpital St Vincent de Paul, Lille and 5Service de Biologie de la Reproduction, CHRU, Lille, France

6 To whom correspondence should be addressed at: Laboratoire de Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 22, avenue Camille Desmoulins, CS 93837, F-29238 Brest cedex 3, France. Email: marc.debraekeleer{at}univ-brest.fr

The objective of this study was to determine the aneuploidy level in spermatozoa in two men with globozoospermia. Sperm nuclei were analysed by fluorescence in-situ hybridization (FISH) in two infertile males with globozoospermia. Dual FISH for chromosomes 7 and 9, 13 and 21, and triple FISH for chromosomes X, Y, and 18 was performed. The main outcome measured was meiotic segregation differences between both globozoospermic men and controls. A statistically significant difference in disomies 13 and 21 was found between patients 1 and 2. The diploidy rate of spermatozoa of patient 1 (0.876%) was significantly increased compared with that of patient 2 (0.304%) and control men (0.293%). In conclusion there seems to be a slightly increased frequency of aneuploidy in round-headed spermatozoa. However, it is unlikely that these aneuploid spermatozoa would be used in assisted reproduction techniques.

Key words: cytogenetics/chromosomal abnormality/globozoospermia/meiotic segregation/male infertility/FISH

* Both authors share first authorship


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