Mol. Hum. Reprod. Advance Access originally published online on October 29, 2004
Molecular Human Reproduction 2004 10(12):911-915; doi:10.1093/molehr/gah120
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Polymorphisms of genes involved in innate immunity: association with preterm delivery
1Department of Pediatrics, and 2Obstetrics and Gynecology, University of Luebeck, 3Childrens Hospital auf der Bult, Hannover, 4University Childrens Hospital, Mannheim, 5Childrens Hospital Kassel, 6Childrens Hospital St. Hedwig, Regensburg, 7Childrens Hospital St. Jürgen-Straße, Bremen and 8Childrens Hospital Saarbrücken, Germany
9 To whom correspondence should be addressed at: Department of Paediatrics, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Email: goepel{at}paedia.ukl.mu-luebeck.de
An altered inflammatory activity due to functionally relevant polymorphisms of the innate immune system may influence pathways leading to labour and, therefore, impact on the frequency of preterm birth. We examined five polymorphisms of the innate immune system in a large cohort of preterm very-low-birth-weight (VLBW, n=909) and term-born infants (n=491) and their mothers (n=747). The primary outcome was preterm versus term birth. Frequencies of polymorphisms in mothers of term-born infants versus mothers of VLBW infants and term infants versus preterm VLBW infants (singletons) are given. Homozygous CD14-159T: 18.5 versus 21.8% (mothers) and 19.6 versus 21.2% (infants). Homozygous interleukin IL-6-174G: 28.8 versus 38% (P=0.018, mothers) and 30 versus 32.7% (infants). Homozygous or heterozygous nuclear oligomerization domain NOD2-3020insC: 6.9 versus 6.1% (mothers) and 5.7 versus 5.1% (infants). Heterozygous or homozygous toll-like-receptor TLR2-Arg753Gln: 6.9 versus 6.1% (mothers) and 5.7 versus 5.1% (infants). Homozygous or heterozygous TLR4-896G: 8.1 versus 11.5% (mothers) and 11.6 versus 10.5% (infants). Although the homozygous maternal IL-6-174G genotype was found to be independently associated with preterm delivery in multivariate regression analysis, the incidence of intrauterine infection was not significantly increased in mothers of preterm VLBW-infants, carrying this or other polymorphisms of the innate immune system. The overall influence of the investigated polymorphisms on the development of preterm delivery seems moderate, since only the maternal IL6-174G genotype was associated with preterm birth and none of the polymorphisms were associated with intrauterine infection as the cause of preterm birth.
Key words: innate immunity/interleukin/intrauterine infection/preterm delivery/toll-like receptor
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. C. Svensson, S. Sandin, S. Cnattingius, M. Reilly, Y. Pawitan, C. M. Hultman, and P. Lichtenstein Maternal Effects for Preterm Birth: A Genetic Epidemiologic Study of 630,000 Families Am. J. Epidemiol., December 1, 2009; 170(11): 1365 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Velez, S. J. Fortunato, S. M. Williams, and R. Menon Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth Hum. Mol. Genet., June 1, 2008; 17(11): 1619 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Awomoyi, P. Rallabhandi, T. I. Pollin, E. Lorenz, M. B. Sztein, M. S. Boukhvalova, V. G. Hemming, J. C. G. Blanco, and S. N. Vogel Association of TLR4 Polymorphisms with Symptomatic Respiratory Syncytial Virus Infection in High-Risk Infants and Young Children J. Immunol., September 1, 2007; 179(5): 3171 - 3177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Vogel, A. A. Awomoyi, P. Rallabhandi, and A. E. Medvedev Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview Innate Immunity, December 1, 2005; 11(6): 333 - 339. [Abstract] [PDF]
|
|