Skip Navigation


Mol. Hum. Reprod. Advance Access originally published online on March 2, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow An erratum has been published
Right arrow All Versions of this Article:
10/4/259    most recent
gah037v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lee, J.
Right arrow Articles by Rhee, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, J.
Right arrow Articles by Rhee, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction, Vol. 10, No. 4, pp. 259-264, 2004
© European Society of Human Reproduction and Embryology 2004

Developmental stage-specific expression of Rbm suggests its involvement in early phases of spermatogenesis

Jungmin Lee1, Jinpyo Hong1, Euisu Kim1, Kyungjin Kim1, Soo Woong Kim2, Hanumanthappa Krishnamurthy3, Sanny S.W. Chung3, Debra J. Wolgemuth3 and Kunsoo Rhee1,4

1School of Biological Sciences, Seoul National University, Seoul 151-742, 2Department of Urology, Seoul National University College of Medicine, Seoul 110-744, Korea and 3Columbia University College of Physicians and Surgeons, Departments of Genetics and Development and Obstetrics and Gynecology and The Institute of Human Nutrition, New York, NY 10032, USA

4 To whom correspondence should be addressed. e-mail: rheek{at}snu.ac.kr

Rbm is a male infertility gene located on the Y chromosome that is expressed in the testis. To investigate the specific events of spermatogenesis in which Rbm plays a role, the precise pattern of expression of Rbm in the mouse testis was determined. An antibody was generated against the Rbm protein and used to detect a single specific band of 43 kDa in size in mouse testicular lysates. In situ hybridization, immunoblot and immunohistochemistry analyses together indicated that Rbm was expressed in spermatogonia, preleptotene spermatocytes, late leptotene to early pachytene spermatocytes but not in mid-pachytene spermatocytes or subsequent stages of differentiation, including haploid germ cells. These observations suggest that Rbm functions in early but not later stages of male germ cell development.

Key words: Key words: male infertility/Rbm/spermatogenesis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
I. Ehrmann, C. Dalgliesh, A. Tsaousi, M. P. Paronetto, B. Heinrich, R. Kist, P. Cairns, W. Li, C. Mueller, M. Jackson, et al.
Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse
Hum. Mol. Genet., September 15, 2008; 17(18): 2803 - 2818.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. Han, H. Song, I. Moon, R. Augustin, K. Moley, M. Rogers, and H. Lim
Utilization of DR1 as true RARE in regulating the Ssm, a novel retinoic acid-target gene in the mouse testis
J. Endocrinol., March 1, 2007; 192(3): 539 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Wang, B. L. Sartini, C. F. Millette, and D. L. Kilpatrick
A Developmental Switch in Transcription Factor Isoforms During Spermatogenesis Controlled by Alternative Messenger RNA 3'-End Formation
Biol Reprod, September 1, 2006; 75(3): 318 - 323.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.