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Mol. Hum. Reprod. Advance Access originally published online on March 2, 2004
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Molecular Human Reproduction, Vol. 10, No. 5, pp. 321-324, 2004
© European Society of Human Reproduction and Embryology 2004

Vascular endothelial growth factor gene polymorphisms and pre-eclampsia

Dimitrios Papazoglou1,5, Georgios Galazios2, Michael I. Koukourakis3, Ioannis Panagopoulos4, Emmanuel N. Kontomanolis2, Konstantinos Papatheodorou1 and Efstratios Maltezos1

1Second Department of Internal Medicine, Medical School, 2Department of Obstetrics and Gynecology, Medical School, 3Department of Radiotherapy–Oncology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece and 4Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden

5 To whom correspondence should be addressed at: Patriarhou Grigoriou 97–99, 68100 Alexandroupolis, Greece. e-mail: dapap{at}otenet.gr

Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. Our present study was undertaken to identify associations between three functional VEGF gene polymorphisms, linked with altered VEGF gene responsiveness, and pre-eclampsia. The study involved 42 pre-eclamptic and 73 healthy control women who were genotyped for the –2578C/A, –634G/C and 936C/T polymorphisms of the VEGF gene. No significant association between genotypic or allelic frequencies in women with pre-eclampsia relative to controls was found. A statistically significant difference was found for allelic frequencies of the 936C/T polymorphism between women with severe pre-eclampsia and controls (odds ratio: 2.70; 95% confidence interval: 1.09–6.63; P = 0.019). VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia. The presence of the 936T allele probably has a considerable effect on disease modification.

Key words: Key words: pre-eclampsia/polymorphisms/vascular endothelial growth factor


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