Mol. Hum. Reprod. Advance Access originally published online on March 25, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Human Reproduction, Vol. 10, No. 6, pp. 399-407, 2004
© European Society of Human Reproduction and Embryology 2004
Cyr61, a deregulated gene in endometriosis
1Institute of Anatomy, University Hospital, 45122 Essen, 2Research Laboratories of Schering AG, 13342 Berlin, 3Department of Orthopaedy, University of Wuerzburg, 97074 Wuerzburg and 4Department of Gynaecology, University Hospital, 49076 Osnabrueck, Germany 6Both authors contributed equally to this study.
5 To whom correspondence should be addressed. e-mail: e.winterhager{at}uni-essen.de
Gene expression profiling was performed to identify genes involved in the development of endometriosis. In the secretory phase of the menstrual cycle, several estrogen-regulated genes were up-regulated in endometria of women with endometriosis. The most consistent regulation with one of the highest factors was observed for the Cyr61 gene, which codes for a secreted, cysteine-rich, heparin-binding protein that promotes cell adhesion, migration, and neovascularization. Estrogen responsiveness of endometrial Cyr61 expression was suggested by the higher expression during the proliferative phase and the reduction observed in human endometrial fragments grafted into nude mice subsequently treated with an anti-estrogen. The expression level of Cyr61 was found to be further increased in ectopic endometriotic lesions, as compared to eutopic endometria. In these lesions, an imbalance in expression of the estrogen-converting enzymes 17ß-hydroxysteroid dehydrogenase type 1 and 2 was found, which might explain the elevated Cyr61 level. However, Cyr61 expression was not altered in endometriotic lesions of women treated with a GnRH agonist. These results suggest that Cyr61 may represent a gene characteristic for endometriosis and also play an important role in the development and persistence of endometriotic lesions.
Key words: Cyr61/endometriosis/estrogen/human endometrium/microarray
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Gashaw, S. Stiller, C. Boing, R. Kimmig, and E. Winterhager Premenstrual Regulation of the Pro-Angiogenic Factor CYR61 in Human Endometrium Endocrinology, May 1, 2008; 149(5): 2261 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Horne and D. L. Blithe Progesterone receptor modulators and the endometrium: changes and consequences Hum. Reprod. Update, November 1, 2007; 13(6): 567 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hever, R. B. Roth, P. Hevezi, M. E. Marin, J. A. Acosta, H. Acosta, J. Rojas, R. Herrera, D. Grigoriadis, E. White, et al. Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator PNAS, July 24, 2007; 104(30): 12451 - 12456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. MacLaughlan, W. A. Palomino, B. Mo, T. D. Lewis, R. A. Lininger, and B. A. Lessey Endometrial Expression of Cyr61: A Marker of Estrogenic Activity in Normal and Abnormal Endometrium Obstet. Gynecol., July 1, 2007; 110(1): 146 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Laschke and M. D. Menger In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis Hum. Reprod. Update, July 1, 2007; 13(4): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Grummer Animal models in endometriosis research Hum. Reprod. Update, September 1, 2006; 12(5): 641 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, H. Ni, X.-H. Ma, S.-J. Hu, L.-M. Luan, G. Ren, Y.-C. Zhao, S.-J. Li, H.-L. Diao, X. Xu, et al. Global analysis of differential luminal epithelial gene expression at mouse implantation sites. J. Mol. Endocrinol., August 1, 2006; 37(1): 147 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Hastings, K. S. Jackson, P. A. Mavrogianis, and A. T. Fazleabas The Estrogen Early Response Gene FOS Is Altered in a Baboon Model of Endometriosis Biol Reprod, August 1, 2006; 75(2): 176 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sherwin, R. Catalano, and A. Sharkey Large-scale gene expression studies of the endometrium: what have we learnt? Reproduction, July 1, 2006; 132(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gashaw, J. M. Hastings, K. S. Jackson, E. Winterhager, and A. T. Fazleabas Induced Endometriosis in the Baboon (Papio anubis) Increases the Expression of the Proangiogenic Factor CYR61 (CCN1) in Eutopic and Ectopic Endometria Biol Reprod, June 1, 2006; 74(6): 1060 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kunz, D. Beil, P. Huppert, M. Noe, S. Kissler, and G. Leyendecker Adenomyosis in endometriosis--prevalence and impact on fertility. Evidence from magnetic resonance imaging Hum. Reprod., August 1, 2005; 20(8): 2309 - 2316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-M. Kim, J.-H. Park, S.-K. Chung, J.-Y. Kim, H.-Y. Hwang, K.-C. Chung, I. Jo, S.-I. Park, and J.-H. Nam Coxsackievirus B3 Infection Induces cyr61 Activation via JNK To Mediate Cell Death J. Virol., December 15, 2004; 78(24): 13479 - 13488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chen, S.-J. Leu, V. Todorovic, S. C.-T. Lam, and L. F. Lau Identification of a Novel Integrin {alpha}v{beta}3 Binding Site in CCN1 (CYR61) Critical for Pro-angiogenic Activities in Vascular Endothelial Cells J. Biol. Chem., October 15, 2004; 279(42): 44166 - 44176. [Abstract] [Full Text] [PDF]
|
|