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Mol. Hum. Reprod. Advance Access originally published online on February 11, 2005
Molecular Human Reproduction 2005 11(3):161-166; doi:10.1093/molehr/gah146
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Molecular Human Reproduction Vol. 11 No. 3 © European Society of Human Reproduction and Embryology 2005; all rights reserved

HCG up-regulates survivin mRNA in human granulosa cells

Yukiyo Kumazawa1,3, Kazuhiro Kawamura1, Toshiharu Sato1, Naoki Sato1, Yoshitomo Konishi1, Yosushi Shimizu1, Jun Fukuda1, Hideya Kodoma2 and Toshinobu Tanaka1

1Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School
of Medicine, 1-1-1 Hondo, Akita, 010-8543, and 2Faculty of Health and Science, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan

3 To whom correspondence should be addressed at: Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan. Email: kakki{at}bk9.so-net.ne.jp

The apoptosis of granulosa cells is involved in follicular atresia and degeneration of the corpus luteum. The mechanisms that regulate follicular atresia and luteal degeneration remain obscure. Survivin is a member of the family of inhibitors of apoptosis protein that is expressed during fetal development and in cancer tissues. The present study investigates the expression of survivin, as well as its regulation and function in granulosa cells. We identified survivin at the protein level in granulosa cells and detected not only survivin but also splice-variant transcripts in human and mouse granulosa-luteal cells. One-step real-time PCR analysis revealed that HCG increases the amount of survivin mRNA expressed in cultured human granulosa cells. These results suggest that survivin is involved in supporting luteal function, and that HCG contributes to this role.

Key words: gonadotrophin/granulosa cells/inhibitors of apoptosis protein/ovary/survivin


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