Mol. Hum. Reprod. Advance Access originally published online on February 4, 2005
Molecular Human Reproduction 2005 11(3):207-210; doi:10.1093/molehr/gah151
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An A>G polymorphism at position –670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction
1First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary and 2Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
3 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, New York, NY 10021, USA. Email: switkin{at}med.cornell.edu
Fas-mediated apoptosis of maternal lymphocytes during pregnancy has been postulated to prevent the development of pre-eclampsia. A single adenine (A) to guanine (G) polymorphism at position –670 in the Fas gene (TNFRSF6) results in decreased Fas synthesis. The association between this polymorphism and pre-eclampsia in Hungarian women was investigated. In a case–control study, buccal swabs from 38 pregnant women with pre-eclampsia and 89 normotensive controls were analysed for the TNFRSF6–670 polymorphism. Investigators were blinded to clinical outcomes. Maternal homozygosity for the TNFRSF6–670*A occurred in 33 (37.1%) normotensive pregnant women as compared to only 5 (16.1%) of 31 pre-eclamptic pregnant women who delivered at <37 weeks gestation (P=0.04). The carriage rate of the TNFRSF6–670*G variant was also higher among these patients (59.7%) than among normotensive controls (42.1%; P=0.01). There was no relation between the polymorphism and the pre-eclampsia diagnosed at 
37 weeks. Among pre-eclamptic patients with an intrauterine growth restriction (IUGR) neonate, eight (57.2%) were TNFRSF6–670*G homozygous as opposed to 3 (17.6%) of 17 pre-eclamptics who did not have IUGR (P=0.03) and 19 (21.3%) normotensive controls (P=0.008). Carriage of the TNFRSF6–670 polymorphism in the neonate was not associated with pre-eclampsia or IUGR. Maternal possession of the TNFRSF6–670*G increases the risk for pre-eclampsia and pre-eclampsia-associated IUGR in women who deliver at <37 weeks.
Key words: Fas/genetic polymorphism/intrauterine growth restriction/pre-eclampsia/TNFRSF6
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