Skip Navigation


Mol. Hum. Reprod. Advance Access originally published online on April 22, 2005
Molecular Human Reproduction 2005 11(5):361-364; doi:10.1093/molehr/gah173
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
11/5/361    most recent
gah173v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sun, F.
Right arrow Articles by Martin, R.H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sun, F.
Right arrow Articles by Martin, R.H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

Meiotic studies in an azoospermic human translocation (Y;1) carrier

F. Sun1,2, M. Oliver-Bonet1,2, P.J. Turek3, E. Ko2 and R.H. Martin1,2,4

1Department of Medical Genetics, University of Calgary, Calgary, Canada T2N 4N1, 2Department of Genetics, Alberta Children's Hospital, Calgary, Canada T2T 5C7 and 3Departments of Urology, Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143-1695, USA

4 To whom correspondence should be addressed at: Department of Genetics, Alberta Children's Hospital, 1820 Richmond Road S.W., Calgary, Alberta, Canada T2T 5C7. Email: rhmartin{at}ucalgary.ca

A reciprocal translocation between the long arm of the Y chromosome and the long arm of chromosome 1 was observed in an infertile man with non-obstructive azoospermia. The study was performed using a combination of techniques: immunocytogenetic analysis, which allows the detection of synaptonemal complexes (SCs) and recombination sites (MLH1) simultaneously, and fluorescence in-situ hybridization analysis. Meiotic pairing analysis on 100 pachytene spreads showed the presence of a quadrivalent containing chromosomes 1 and Y. There were many abnormalities in chromosome pairing and recombination. These abnormalities included a great reduction of recombination events (as many as one fifth of the SCs had no MLH1 foci), and high proportions of unpaired regions and discontinuities in the SCs. We discuss the possibility that infertility in this patient may be due to transcriptional repression of part of chromosome 1 involved in the translocation, silencing some genes necessary for the progression of meiosis and causing defective meiotic pairing and recombination.

Key words: immunocytogenetics/meiosis/meiotic recombination/sex-autosome translocation/synaptic anomalies


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
R.H. Martin
Cytogenetic determinants of male fertility
Hum. Reprod. Update, June 4, 2008; (2008) dmn017v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. A. Ferguson, V. Chow, and S. Ma
Silencing of unpaired meiotic chromosomes and altered recombination patterns in an azoospermic carrier of a t(8;13) reciprocal translocation
Hum. Reprod., April 1, 2008; 23(4): 988 - 995.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.