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Mol. Hum. Reprod. Advance Access originally published online on July 8, 2005
Molecular Human Reproduction 2005 11(7):471-476; doi:10.1093/molehr/gah186
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor

Hirohiko Watanabe1,2, Kohsuke Nonoguchi1,2, Toshiharu Sakurai2, Tomoko Masuda2, Katsuhiko Itoh2 and Jun Fujita2,3

1Daigo Watanabe Clinic and 2Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan

3 To whom correspondence should be addressed at: Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. E-mail: jfujita{at}virus.kyoto-u.ac.jp

Decidualization of the endometrial stromal cells (ESC), considered to be stimulated by progesterone and/or cAMP, is crucial for embryo implantation and placentation. In this study, we isolated a novel clone encoding decidual protein induced by progesterone (Depp) from a human ESC cDNA library enriched with progesterone-inducible genes. Depp mRNA was expressed in various human tissues including placenta, ovary and kidney. Increased expression of Depp was observed in endometria during mid- and late-secretory phases and 1st trimester deciduas. In vitro, Depp mRNA was induced in ESC within 30 min of progesterone treatment, which was inhibited by the antiprogestin RU486. Androgen alone also induced Depp expression. Depp increased the level of phosphorylated Erk and activated the Elk-1 transcription factor in human embryonal kidney 293 cells, suggesting that Depp modulates the effects of progesterone during decidualization and in the decidua by affecting gene expression. Elucidation of the biological function of Depp in the endometrium will facilitate our understanding of the molecular mechanisms of decidualization and placental development.

Key words: decidualization/Elk-1/endometrium/MAPK/progesterone


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