Mol. Hum. Reprod. Advance Access originally published online on February 2, 2006
Molecular Human Reproduction 2006 12(1):35-39; doi:10.1093/molehr/gal002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China
1Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital and 2Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China
3 To whom correspondence should be addressed: Hebei Cancer Institute, Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China. E-mail: lykx1962{at}yahoo.com.cn
Matrix metalloproteinases (MMPs) may contribute to the development of endometriosis. The aim of this study was to assess the effects of the polymorphisms in the promoters of MMP-7 (181A/G) and MMP-9 (1562C/T) on the risk of occurrence of endometriosis and adenomyosis. We genotyped 219 patients (143 women with endometriosis, 76 women with adenomyosis) and 160 control women in North China. There was a significant difference in frequency of the MMP-7 genotype between endometriosis and controls (P = 0.01) and also between adenomyosis and controls (P = 0.01). The frequency of the G allele in two groups of patients (7.3 and 7.9%) was significantly higher than in the controls (2.8%) (P = 0.01 and 0.01, respectively). Compared to the A/A genotype, the genotype with the -181G allele showed a significantly increased susceptibility to both diseases, with adjusted odds ratio of 2.62 [95% confidence interval (CI) = 1.17–5.87] for endometriosis and 3.14 (95% CI = 1.26–7.81) for adenomyosis. However, the overall genotype and allelotype distribution of the MMP-9 in the two case groups were not different from that of controls. We conclude that MMP-7–181A/G polymorphism has a potential to be a susceptibility factor for endometriosis and adenomyosis while MMP-9–1562C/T polymorphism may not provide a useful marker to predict susceptibility to endometriosis and adenomyosis, at least in women from North China.
Key words: adenomyosis/endometriosis/matrix metalloproteinase-7/matrix metalloproteinase-9/single nucleotide polymorphism
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C.B. Tempfer, M. Simoni, B. Destenaves, and B.C.J.M. Fauser Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis Hum. Reprod. Update, September 19, 2008; (2008) dmn040v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Borghese, J.-D. Chiche, D. Vernerey, C. Chenot, O. Mir, G. Bijaoui, C. Bonaiti-Pellie, and C. Chapron Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression Hum. Reprod., May 1, 2008; 23(5): 1207 - 1213. [Abstract] [Full Text] [PDF]
|
|