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Mol. Hum. Reprod. Advance Access originally published online on January 18, 2006
Molecular Human Reproduction 2006 12(1):7-10; doi:10.1093/molehr/gah254
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Oct-4 expression in human endometrium

C. Matthai1, R. Horvat2, M. Noe1, F. Nagele1, A. Radjabi3, M. van Trotsenburg1, J. Huber1 and A. Kolbus1,4

1Department of Gynecological Endocrinology and Reproductive Medicine, 2Department of Clinical Pathology and 3Department of Gynecology and Obstetrics, Medical University of Vienna, Waehringer Guertel, Vienna, Austria

4 To whom correspondence should be addressed at: Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 5Q, Vienna A-1090, Austria. E-mail: andrea.kolbus{at}meduniwien.ac.at

The transcription factor Oct-4 is crucial for the maintenance of cell pluripotency and is known to be expressed in embryonic stem cells, germ cells and whole embryos at various stages of development. Oct-4 regulates cell fate in a dose-dependent manner and plays a key role in germ-cell tumours. In the past, several stem-cell markers have been detected, and their role in the pathogenesis of diseases has been discussed frequently. Thus, we investigated the expression of Oct-4 comparing its occurrence in endometrium of healthy and diseased women using immunohistochemistry (IHC) and RT–PCR. IHC demonstrated Oct-4 expression in 25 of 60 sections (42%), respectively in 11 out of 25 patients (44%). Oct-4 mRNA was detected by RT–PCR in all tested samples (9 of 9) of endometrium, although the levels of expression varied. To our knowledge, this is the first study demonstrating Oct-4 expression in human endometrium.

Key words: endometrium/Oct-4/stem cells/transcription factor


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