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Mol. Hum. Reprod. Advance Access originally published online on September 7, 2006
Molecular Human Reproduction 2006 12(11):695-701; doi:10.1093/molehr/gal070
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy

Alison J. Tyson-Capper1,3, David M.W. Cork1, Emily Wesley1, Elizabeth A. Shiells1 and Andrew D. Loughney2

1School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne and 2Women’s Services, Newcastle upon Tyne Hospitals NHS Trust, Royal Victoria Infirmary, Newcastle upon Tyne, UK

3 To whom correspondence should be addressed at: School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK. E-mail: a.j.tyson-capper{at}ncl.ac.uk

Many complementary or competing signalling pathways bear an influence on the myometrium at any one time, and because the retinoic acid signalling pathway influences differentiation of a wide array of human tissues, this may be one of the determinants of myometrial differentiation during pregnancy. We have explored the novel hypothesis that the retinoids may act as important regulators in controlling the differentiated state of the human myometrium during pregnancy by characterizing the expression profiles for cellular retinoid-binding proteins CRBPI, CRABPI and CRABPII in non-pregnant, pregnant (non-labouring) and labouring human myometrium taken from the functionally distinct upper and lower uterine segments. In addition, we have investigated the effect of all-trans retinoic acid (ATRA) on the expression of several retinoic acid response genes including cyclooxygenase-2 (COX-2) and connexin-43 (Cx-43). Different spatial and temporal patterns of expression were observed for CRBPI, CRABPI and CRABPII within the upper and lower uterine segments through the three trimesters of pregnancy and in labour. Furthermore, the expression of COX-2, Cx-43, CRABPI, the transcription factor c-Jun and the retinoic acid receptor RARß altered in response to different concentrations of ATRA, suggesting that the differential expression of cellular retinoid-binding proteins may lead to different levels of retinoic acid being delivered to its nuclear targets, leading to the differential expression of specific target genes within the myometrium during pregnancy.

Key words: all-trans retinoic acid/cellular retinoid-binding proteins/myometrium/parturition/pregnancy/retinoic acid


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[Abstract] [PDF]


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