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Mol. Hum. Reprod. Advance Access originally published online on October 13, 2006
Molecular Human Reproduction 2006 12(12):771-776; doi:10.1093/molehr/gal084
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion

W. Zammiti1, N. Mtiraoui1, E. Cochery-Nouvellon2, T. Mahjoub1, W.Y. Almawi3,4 and J.-C. Gris2

1Research unit of Haematological and Autoimmune diseases, Faculty of Pharmacy, Monastir, Center University, 2Faculty of Biological and Pharmaceutical Sciences, Montpellier-1 University, Montpellier, France and 3Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain

4 To whom correspondence should be addressed at: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, PO Box 22979, Manama, Bahrain. E-mail. wyalmawi{at}yahoo.co.uk

Increasing evidence supports a role for altered T helper 1 (Th1)–Th2 cytokine balance in idiopathic recurrent spontaneous abortion (RSA). The aim of this study was to investigate the association of the interleukin 10 (IL-10) promoter polymorphisms -592C/A, -819C/T and -1082A/G with RSA. Women (n = 350) with at least three consecutive spontaneous abortions (RSA cases) and 200 control women with at least two successful pregnancies were included. The frequency of the -819T allele [P = 0.05, odds ratio (OR) = 1.51], but not other single-nucleotide polymorphisms (SNPs), was higher among RSA patients. Complete linkage disequilibrium (LD) was seen between -592C and -819C and -1082G alleles, as well as between -592A and -819T and between -819C and -1082G alleles only among patients. Although the genotype frequencies (except for -819C/C) of the three polymorphisms were comparable between patients and controls, higher frequency of -592A/-819T/-1082A haplotype (OR = 4.01, 95% CI = 1.83–7.95) was seen in cases versus controls. Regression analysis indicated that, after adjusting for potential variables, -592C/A (OR = 3.32, 95% CI = 1.76–6.27) and -819C/T (OR = 5.06, 95% CI = 2.59–9.91) were associated with exclusively early but not exclusively late RSA, where negative association for both was noted. This supports the notion of involvement of IL-10-592C/A and -819C/T polymorphisms as inherited risk factors of idiopathic RSA.

Key words: autoimmunity/autoantibodies/IL-10/recurrent abortion


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[Abstract] [Full Text] [PDF]


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