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Mol. Hum. Reprod. Advance Access originally published online on April 27, 2006
Molecular Human Reproduction 2006 12(6):383-388; doi:10.1093/molehr/gal042
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Transcriptional expression of survivin and its splice variants in endometriosis

Kuniko Fujino, Masatsugu Ueda1, Mikio Takehara, Hikari Futakuchi, Koji Kanda, Yoshiki Yamashita, Yoshito Terai and Minoru Ueki

Department of Obstetrics and Gynecology, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan

1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Osaka Medical College, 2–7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan. E-mail: gyn017{at}poh.osaka-med.ac.jp

Survivin is a novel inhibitor of apoptosis (IAP), and the two splice variants of survivin (survivin-2B and survivin-EX3) have been identified. Gene expression levels of survivin, survivin-2B and survivin-EX3 in 56 ectopic (16 peritoneal red and 16 peritoneal black lesions and 24 ovarian endometriomata) and 13 eutopic endometrial tissues surgically obtained from 42 women with endometriosis (group A) were compared with those in 16 control eutopic endometrium from 16 women without endometriosis (group B) by quantitative RT–PCR analysis. Survivin mRNA expression levels in ectopic endometriotic tissues were significantly higher than those in eutopic endometrium of groups A and B over the whole cycle. Red peritoneal lesions had higher gene expression levels of survivin than black lesions. In contrast, all tissue samples examined showed relatively lower gene expression levels of survivin-2B and survivin-EX3. No cyclic variation was found in survivin and the two splice variants, both in ectopic and in eutopic endometrium. Although there was no significant difference in the ratio of survivin-2B/survivin between ectopic and eutopic endometrium, the ratio of survivin-EX3/survivin in peritoneal endometriotic lesions was significantly higher than that of eutopic endometrium of groups A and B. These results suggest that survivin and survivin-EX3 may be closely linked to escape from apoptosis and the development of endometriosis.

Key words: apoptosis/endometriosis/splice variants/survivin


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R. Gonzalez-Ramos, J. Donnez, S. Defrere, I. Leclercq, J. Squifflet, J.-C. Lousse, and A. Van Langendonckt
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis
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[Abstract] [Full Text] [PDF]


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