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Mol. Hum. Reprod. Advance Access originally published online on July 26, 2006
Molecular Human Reproduction 2006 12(9):525-534; doi:10.1093/molehr/gal060
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© The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Extracellular matrix of the human cyclic corpus luteum

Helen F. Irving-Rodgers1, Barbro E. Friden2, Stephanie E. Morris1, Helen D. Mason3, Mats Brannstrom2, Kiyotoshi Sekiguchi4, Noriko Sanzen4, Lydia M. Sorokin5, Yoshikazu Sado6, Yoshifumi Ninomiya7 and Raymond J. Rodgers1,8

1Department of Obstetrics and Gynaecology, Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia, 2Department of Obstetrics and Gynecology, The Sahlgrenska Academy, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden, 3Basic Medical Sciences and Clinical Developmental Sciences, St. George’s, University of London, London, UK, 4Institute for Protein Research, Osaka University, Suita, Osaka, Japan, 5Institute of Physiological Chemistry and Pathobiochemistry, Muenster University, Muenster, Germany, 6Division of Immunology, Shigei Medical Research Institute and 7Department of Molecular Biology and Biochemistry, Okayama University Medical School, Okayama, Japan

8 To whom correspondence should be addressed at: Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia. E-mail: ray.rodgers{at}adelaide.edu.au

Extracellular matrix regulates many cellular processes likely to be important for development and regression of corpora lutea. Therefore, we identified the types and components of the extracellular matrix of the human corpus luteum at different stages of the menstrual cycle. Two different types of extracellular matrix were identified by electron microscopy; subendothelial basal laminas and an interstitial matrix located as aggregates at irregular intervals between the non-vascular cells. No basal laminas were associated with luteal cells. At all stages, collagen type IV {alpha}1 and laminins {alpha}5, ß2 and {gamma}1 were localized by immunohistochemistry to subendothelial basal laminas, and collagen type IV {alpha}1 and laminins {alpha}2, {alpha}5, ß1 and ß2 localized in the interstitial matrix. Laminin {alpha}4 and ß1 chains occurred in the subendothelial basal lamina from mid-luteal stage to regression; at earlier stages, a punctate pattern of staining was observed. Therefore, human luteal subendothelial basal laminas potentially contain laminin 11 during early luteal development and, additionally, laminins 8, 9 and 10 at the mid-luteal phase. Laminin {alpha}1 and {alpha}3 chains were not detected in corpora lutea. Versican localized to the connective tissue extremities of the corpus luteum. Thus, during the formation of the human corpus luteum, remodelling of extracellular matrix does not result in basal laminas as present in the adrenal cortex or ovarian follicle. Instead, novel aggregates of interstitial matrix of collagen and laminin are deposited within the luteal parenchyma, and it remains to be seen whether this matrix is important for maintaining the luteal cell phenotype.

Key words: collagen type IV/corpus luteum/extracellular matrix/laminin/versican


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