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Mol. Hum. Reprod. Advance Access originally published online on August 31, 2007
Molecular Human Reproduction 2007 13(11):791-796; doi:10.1093/molehr/gam060
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Concentrations of monosaccharides and their amino and alcohol derivatives in human preovulatory follicular fluid

Maciej Józwik1,4, Marcin Józwik2, Cecilia Teng3 and Frederick C. Battaglia3

1Department of Gynecology, Medical University of Bialystok, Sklodowskiej 24 A, 15-276 Bialystok, Poland 2Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Sklodowskiej 24 A, 15-276 Bialystok, Poland 3Division of Perinatal Medicine, University of Colorado at Denver and Health Sciences Center, 13243 East 23rd Avenue, Aurora, CO 80045, USA

4 Correspondence address. Tel: +48-85-7468347; Fax: +48-85-7468682; E-mail: jozwikmc{at}interia.pl

The study purpose was to compare sugar and polyol concentrations in preovulatory ovarian follicular fluid (FF) with those in the circulation. Samples of FF and peripheral venous blood were obtained after an overnight fast from 14 women attending an IVF program. High performance liquid chromatography measurements of seven polyols, two aminohexoses and four hexoses were the main outcome measures. Glucose concentrations in FF and plasma were 2781.26 ± 205.64 and 4431.25 ± 65.17 µM, respectively (P < 0.001). Mannose concentration in FF was 38.99 ± 3.33 µM, significantly lower than plasma concentration (55.38 ± 2.29 µM; P < 0.001). A concentration gradient from plasma to FF was also significant for glycerol (99.41 ± 8.47 versus 74.32 ± 6.54 µM; P < 0.002), galactose (31.69 ± 1.58 versus 26.73 ± 1.93 µM; P < 0.01) and galactosamine (11.49 ± 0.69 versus 6.38 ± 0.59 µM; P < 0.001). The plasma-to-FF concentration difference was greatest for glucose (1649.99 ± 204.09 µM). There was a significant correlation between plasma and FF concentrations for galactose and glycerol. This study supports a substantial utilization of glucose by the oocyte/granulosa cells complex, and documents a significant concentration gradient from plasma to FF for glycerol, mannose, galactose and galactosamine. These plasma–FF differences may reflect both utilization of these carbohydrates by the cells of the preovulatory ovarian follicle and/or transport characteristics of these cells.

Key words: monosaccharides/plasma follicular fluid gradient/glucose/human preovulatory follicular fluid/polyol concentrations

Submitted on July 7, 2007; resubmitted on August 15, 2007; accepted on August 20, 2007.


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