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Mol. Hum. Reprod. Advance Access originally published online on May 22, 2007
Molecular Human Reproduction 2007 13(7):465-471; doi:10.1093/molehr/gam037
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles

Shuping Gao1, Christian De Geyter1,2,3, K. Kossowska1 and Hong Zhang1,2

1 Department of Research, Women's Hospital, University of Basel, Switzerland 2 Department of Obstetrics and Gynecology, University Hospital of Basel, Spitalstrasse 21, CH-4031 Basel, Switzerland

3 Correspondence address. Tel: +41 61 265 9315; Fax: +41 61 265 9194; E-mail: cdegeyter{at}uhbs.ch

We report the characterization of full-length human ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-16, a novel member of the disintegrin and metalloproteinase with thrombospondin motifs (hence ADAMTS) family. ADAMTS-16 is highly expressed both in the kidney and in the ovary, where it is predominantly expressed in the parietal granulosa cells of pre-ovulatory follicles but only slightly expressed in cells of the cumulus oophorus. In fully differentiated luteinizing granulosa cells, follicle-stimulating hormone and forskolin induces expression of ADAMTS-16, suggesting that it is regulated via the cAMP pathway. Luteinizing hormone had a minor effect on the expression of ADAMTS-16. ADAMTS-16 is capable of cleaving {alpha}2-macroglobulin (MG), a common substrate for proteases, which is present at high concentrations in the follicular fluid of ovarian follicles. These studies provide the first evidence that ADAMTS-16 is an active protease and suggest a physiological role of ADAMTS-16 in ovarian follicles, at least during the pre-ovulatory phase.

Key words: ADAMTS-16/ovulation/FSH/ovarian follicle/{alpha}2-macroglobulin


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