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Mol. Hum. Reprod. Advance Access originally published online on June 7, 2007
Molecular Human Reproduction 2007 13(8):527-535; doi:10.1093/molehr/gam036
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© The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome

Xiang Ma1,2, Lu Fan1, Yan Meng2, Zheng Hou1, Yun-Dong Mao2, Wei Wang2, Wei Ding2 and Jia-Yin Liu2,3

1 Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People's Republic of China 2 The Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People's Republic of China

3 Correspondence address. Tel: +86-25-83674442; Fax: +86-25-83674442; E-mail: jyliu{at}njmu.edu.cn

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility, affecting 5–10% of females of reproductive age. Currently, little is known about the changes in whole proteins between PCOS and normal ovaries. In the present study, a proteomic approach comprised two-dimensional gel electrophoresis (2DE) analysis and mass spectroscopy was used to identify proteins and examine expression patterns in three PCOS and normal ovaries. One hundred and ten protein spots were separated and showed different intensities between PCOS and normal ovaries. Sixty-nine proteins associated with cellular metabolism and physiological process were identified from 72 spots. Fifty-four proteins were up-regulated in PCOS ovaries and 15 other proteins were up-regulated in normal ovaries. These data demonstrate, for the first time, the complexity in the regulation of ovarian protein expression in human PCOS, and will provide important insight for a better understanding of the pathogenetic mechanisms underlying this clinical disorder.

Key words: proteome/ovary/PCOS/human


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[Abstract] [Full Text] [PDF]


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