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Mol. Hum. Reprod. Advance Access originally published online on August 19, 2009
Molecular Human Reproduction 2009 15(10):625-631; doi:10.1093/molehr/gap068
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

This article appears in the following Molecular Human Reproduction issue: Special Issue: Mechanisms of Endometriosis [View the issue table of contents]

MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis

R.O. Burney1, A.E. Hamilton2, L. Aghajanova2, K.C. Vo2, C.N. Nezhat3, B.A. Lessey4 and L.C. Giudice2,5

1Division of Reproductive Endocrinology and Infertility, Madigan Army Medical Center, Tacoma, WA, USA 2Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143-0138, USA 3Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, CA, USA 4Reproductive Endocrinology and Infertility Division, Center for Women's Medicine, Greenville, SC, USA

5 Correspondence address. E-mail: giudice{at}obgyn.ucsf.edu

Endometriosis is a common gynecologic disorder characterized by pain and infertility. In addition to estrogen dependence, progesterone resistance is an emerging feature of this disorder. Specifically, a delayed transition from the proliferative to secretory phase as evidenced by dysregulation of progesterone target genes and maintenance of a proliferative molecular fingerprint in the early secretory endometrium (ESE) has been reported. MicroRNAs (miRNAs) are small noncoding RNAs that collectively represent a novel class of regulators of gene expression. In an effort to investigate further the observed progesterone resistance in the ESE of women with endometriosis, we conducted array-based, global miRNA profiling. We report distinct miRNA expression profiles in the ESE of women with versus without endometriosis in a subset of samples previously used in global gene expression analysis. Specifically, the miR-9 and miR-34 miRNA families evidenced dysregulation. Integration of the miRNA and gene expression profiles provides unique insights into the molecular basis of this enigmatic disorder and, possibly, the regulation of the proliferative phenotype during the early secretory phase of the menstrual cycle in affected women.

Key words: endometriosis/endometrium/microRNA/microarray

Submitted on May 5, 2009; resubmitted on August 11, 2009; accepted on August 12, 2009.


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