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Mol. Hum. Reprod. Advance Access originally published online on August 26, 2009
Molecular Human Reproduction 2009 15(11):703-711; doi:10.1093/molehr/gap067
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Recent progress in luteinizing hormone/human chorionic gonadotrophin hormone research

Nafis A. Rahman1,2,3 and C.V. Rao2

1Department of Physiology, Faculty of Medicine, Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland 2Departments of Cell Biology, Molecular and Human Genetics, Obstetrics & Gynecology, Florida International University College of Medicine, Miami, FL 33199, USA

3 Correspondence address. Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland. Fax: +358-2-2502610; E-mail: nafis.rahman{at}utu.fi

The role of luteinizing hormone (LH) and human chorionic gonadotrophin hormone (hCG) in the regulation of normal reproductive functions in males and females is quite well established. Besides the use of hCG in the development of diagnostic immunoassays, it has been successfully used in the induction of final follicular maturation and ovulation in the assisted reproductive technologies. The basic and clinical research on the nongonadal actions of LH/hCG in the recent years has extended the potential of using these hormones in several clinical indications. Hereby we will analyze the advances in the LH/hCG research (briefly emphasizing the nongonadal research), which has the potential for multiple novel therapies in reproductive and the other areas of medicine.

Key words: luteinizing hormone/human chorionic gonadotrophin/luteinizing/human chorionic gonadotrophin receptor/gonadal and nongonadal effects

Submitted on December 19, 2008; resubmitted on July 23, 2009; accepted on August 7, 2009.


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