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Mol. Hum. Reprod. Advance Access originally published online on March 3, 2009
Molecular Human Reproduction 2009 15(5):269-270; doi:10.1093/molehr/gap018
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness

Spyros I. Papamichos1,6, Vassiliki Kotoula2, Basil C. Tarlatzis3, Theodoros Agorastos4, Konstantinos Papazisis5 and Alexandros F. Lambropoulos1

1Laboratory of Molecular Biology, First Department of Obstetrics and Gynaecology, General Regional Hospital Papageorgiou, Aristotle University, Ring Road, 56403 Thessaloniki, Greece 2Department of Pathology, School of Medicine, Aristotle University, Thessaloniki, Greece 3Unit for Human Reproduction, First Department of Obstetrics and Gynaecology, General Regional Hospital Papageorgiou, Aristotle University, Thessaloniki, Greece 4Unit of Gynaecologic Oncology, First Department of Obstetrics and Gynaecology, General Regional Hospital Papageorgiou, Aristotle University, Thessaloniki, Greece 5Applied Molecular Oncology Laboratory, Theagenion Cancer Hospital, Thessaloniki, Greece

6 Correspondence address. Tel: +30-2310-693-280; Fax: +30-2310-991-486; E-mail: spmedauth{at}yahoo.gr

A novel OCT4 alternative spliced variant (OCT 4B1) is deduced to be the isoform present in 59 hESC lines characterised by the International Stem Cell Initiative (ISCI) rather than OCT4A as previously assumed. The new variant may be a more reliable marker of stemness than OCT4A and studies are needed to test this.

Key words: International Stem Cell Initiative/OCT4B1 isoform/spliced variant/human embryonic stem cells/stemness marker

Submitted on December 26, 2008; resubmitted on February 24, 2009; accepted on February 26, 2009.


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