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Mol. Hum. Reprod. Advance Access originally published online on June 23, 2009
Molecular Human Reproduction 2009 15(9):531-538; doi:10.1093/molehr/gap049
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The role of centrosomes in mammalian fertilization and its significance for ICSI

Heide Schatten1,3 and Qing-Yuan Sun2,3,{dagger}

1Department of Veterinary Pathobiology, University of Missouri, 1600 E Rollins Street, Columbia, MO, USA 2State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, #5 Datun Rd, Chaoyang, Beijing 100080, China

3 Correspondence address. Tel: +1-573-882-2396; Fax: +1-573-884-5414; E-mail: SchattenH{at}missouri.edu (H.S.); Tel/Fax: +86-10-64807050; E-mail: sunqy{at}ioz.ac.cn (Q.-Y.S.)

Centrosome integrity is critically important for successful fertilization and embryo development. In humans, the sperm contributes the dominant centrosomal material containing centrioles and centrosomal components onto which oocyte centrosomal proteins assemble after sperm incorporation to form the sperm aster that is essential for uniting sperm and oocyte pronuclei. Increasingly, dysfunctional sperm centrosomes have been identified as a factor for sperm-derived infertility and heterologous Intracytoplasmic Sperm Injection (ICSI) has been used to assess centrosome and sperm aster formation and clearly established a relationship between infertility and sperm centrosomal dysfunction. ICSI has been used successfully to provide novel treatment to overcome male factor infertility and it may open up new possibilities to correct specific sperm-related centrosome dysfunctions at molecular levels. New data indicate that it is now possible to replace dysfunctional centrosomes with functional donor sperm centrosomes which may provide new treatment for couples in which infertility is a result of centrosome-related sperm dysfunctions.

Key words: centrosomes/infertility/sperm aster/centrosome integrity

{dagger} Presented at the Beijing International Symposium on Reproductive Biology and invited for submission to MHR.

Submitted on November 22, 2008; resubmitted on June 3, 2009; accepted on June 18, 2009.


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