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Molecular Human Reproduction Vol. 2, NUMBER 1 pp. 2-8, 1996
© European Society of Human Reproduction and Embryology 1996

research-article

Genetic regulation of gametogensis

The receptor encoded by the human C-MET oncogene is expressed in testicular tissue and on human spermatozoa

Christophe E. Depuydt1, Adel Zalata2, Christian R. de Potter3, John van Emmelo4 and Frank H. Comhaire1,5

1Department of Internal Medicine, Section Endocrinology and Metabolic Diseases, University Hospital Ghent De Pintelaan 185, 9000, Ghent, Belgium 2On leave of absence from Mansoura University El-Mansoura, Egypt 3N.Goormaghtigh Institute for Pathology, University Hospital Ghent 4Laboratory of Bacteriology and Virology, University Hospital Ghent

To whom correspondence should be addressed at: 5To whom correspondence should be addressed

Because of its distinctive ability to act as a mitogen, a mitogen and a morphogen, hepatocyte growth factor/ scatter factor (HGF/SF) has all the characteristics of a molecule able to function in regulatory networks of motility, such as the spermatogenic epithelium, and this through binding of its receptor p190MET (C-MET). In this study we report the expression of C-MET in the human seminiferous epithelium and on spermatozoa from men being treated for infertility and sperm donors. The presence of C-MET was demonstrated by immunochemistry on the cell membrane of spermatogonia, spermatocytes, spermatids and on spermatozoa, whereas Sertoli cells and Leydig cells did not show expression. Comparison of C-MET expression on spermatozoa of the 90% Percoll layer of subfertile patients and donors revealed clearly two distinct groups (unpaired t-test, P < 0.001), whereas comparison of C-MET expression on spermatozoa in the 47% Percoll layer was not significantly different between patients and donors. In addition, there was a significant inverse correlation between sperm concentration and the C-MET expression of spermatozoa in the 90% Percoll layer (r = –0.80, 95% confidence interval, –0.92 to –0.55; P < 0.0001), but not with the C-MET expression of spermatozoa in the 47% Percoll layer. In conclusion, the presence of C-MET was demonstrated in the seminiferous epithelium and on mature and immature spermatozoa, indicating a role for this growth factor receptor in the differentiation and/or migration that occurs during human spermatogenesis.

C-MET/male infertility/spermatozoa/testis


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