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Molecular Human Reproduction Vol. 2, NUMBER 1 pp. 60-62, 1996
© European Society of Human Reproduction and Embryology 1996

research-article

Diagnosing and preventing inherited diseases

Management of rhesus isoimmunization by preimplantation genetic diagnosis

Rachel Avner1,4, Benjamin E. Reubinoff2, Alex Simon3, Bat-Sheva Zentner3, Adam Friedmann1, Stella Mitrani-Rosenbaum1 and Neri Laufer3

1The Unit for Molecular Biology and Genetic Engineering, Hadassah University Hospital, Mount-Scopus P.O. Box 24035, Jerusalem 91240 2Department of Obstetrics and Gynecology, Hadassah University Hospital Ein-Kerem Jerusalem 91120 3Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount-Scopus Jerusalem 91240, Israel

To whom correspondence should be addressed at: 4To whom correspondence should be addressed

A genetic assay by single blastomere analysis was developed for rhesus (RhD) blood group typing of early cleavage stage embryos. The method, which is based on the simultaneous amplification of an RhD-specrfic sequence and an internal control in single cells, was applied for the selective transfer of RhD-negative embryos in a family of an RhD sensitized woman and a heterozygote partner. The RhD status of two out of three biopsied embryos was determined. According to their amplified products, both were typed as RhD-negative and transferred to the uterus. Pregnancy was not achieved.


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