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Molecular Human Reproduction Vol. 2, NUMBER 3 pp. 195-202, 1996
© European Society of Human Reproduction and Embryology 1996

research-article

Molecular approaches to the diagnosis of malse infertility

J. Jeremias1 and S.S. Witkin

Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Cornell University Medical College 515 East 71st Street, New York, NY 10021, USA

To whom correspondence should be addressed at: 1To whom correspondence should be addressed

The introduction of the polymerase chain reaction (PCR) as a technique to selectively amplify and identify specific DNA and RNA sequences has revolutionized the field of molecular medicine. Application of these newly developed molecular techniques to the field of male infertility has made the delineation of subtle causes of infertility—an inapparent genital tract infection, immune system activation within the genital tract, mutations in sperm mitochondrial or chromosomal DNA, alterations in sperm components involved in receptor-ligand interactions, and production of sperm autoantibodies—all increasingly amenable to clinical analysis. Continued investigations at the molecular level of the causes of male infertility will also lead to novel treatment regimens as well as development of new methods of fertility regulation

immunology/male infertility/molecular genetics/polymerase chain reaction/receptor–ligand inter–actions


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