Molecular Human Reproduction Vol. 2, NUMBER 4 pp. 239-243, 1996
© European Society of Human Reproduction and Embryology 1996
research-article |
Molecular interactions during pregnancy
Distribution of interleukin-6 in maternal and embryonic tissues during the first trimester
1Academic Department of Obstetrics and Gynaecology, University College London Medical School London, UK 2Departments of Clinical Chemistry, Free University of Brussels (ULB) Brussels 3Departments of Immunology, Academic Hospital Erasme, Free University of Brussels (ULB) Brussels 4Laboratory of Radiolmmunology, University of Liege (ULG) Liege 5Institute of Pathology Loverval, Belgium
To whom correspondence should be addressed at: 6To whom correspondence should be addressed at: Academic Department of Obstetrics and Gynaecology, University College London Medical School, 86-96 Chenies Mews, London WC1E 6HX, UK
Interleukin-6 (IL-6) distribution was investigated in coelomic fluid, amniotic fluid, maternal serum, decidua and placental villous tissue collected from 16 normal pregnancies between 7 and 12 weeks of gestation. IL-6 levels in fluids and tissues were measured by an immunoenzymatic assay and mouse monoclonal antibodies specific for IL-6 were used to localize immunohistochemically IL-6 in decidual and placental tissue. IL-6 was detected in all samples of coelomic and amniotic fluids and in most extracts of placental and decidual tissues. IL-6 concentration was significantly (P < 0.005) higher in the coelomic fluid than in amniotic fluid and was positively correlated with gestational age. Immunostaining for IL-6 was present in both syncytiotrophoblast and extra-villous trophoblast. IL-6 was in significantly (P < 0.001) higher concentration in decidual than in placental tissues. These data indicate that IL-6 is normally present in coelomic and amniotic fluids of early pregnancy and that IL-6 concentrations mainly result from the accumulation of trophoblastic-derived IL-6. During the first trimester IL-6 could play a role in tissue remodelling associated with placentation but also in the haematopoiesis function of the secondary yolk sac and in the generation of new vessels in placental villous tissue.
coelomic fluid/early placenta/first trimester/interleukin-6/pregnancy
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. S. Fitzgerald, T. G. Poehlmann, E. Schleussner, and U. R. Markert Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum. Reprod. Update, April 17, 2008; (2008) dmn010v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hirata, T. Sato, M. Tsumagari, A. Shimada, H. Nakano, K. Hashizume, and A. Ito Differential Regulation of the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Cytokines and Growth Factors in Bovine Endometrial Stromal Cells and Trophoblast Cell Line BT-1 In Vitro Biol Reprod, April 1, 2003; 68(4): 1276 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meisser, P. Cameo, D. Islami, A. Campana, and P. Bischof Effects of interleukin-6 (IL-6) on cytotrophoblastic cells Mol. Hum. Reprod., November 1, 1999; 5(11): 1055 - 1058. [Abstract] [Full Text] [PDF]
|
|