Molecular Human Reproduction, Vol 3, 27-45, Copyright © 1997 by Oxford University Press
DL Hulboy, LA Rudolph and LM Matrisian
The organs of the adult reproductive system can undergo extensive
remodelling, experiencing rapid changes in tissue mass and function. Much
of this matrix remodelling is attributed to the action of matrix
metalloproteinases. Matrix metalloproteinase family members are expressed
in a highly-regulated manner in many reproductive processes, including
menstruation, ovulation, implantation, and uterine, breast, and prostate
involution. Metalloproteinase concentrations and activity can be regulated
by reproductive hormones, as well as by growth factors and cytokines that
participate in reproductive events. In addition to playing a role in the
loss of connective tissue mass, the metalloproteinases can influence the
phenotype of the cellular components of the tissues, altering basic
cellular functions such as proliferation, differentiation, and apoptosis.
This review focuses on the expression of matrix metalloproteinases in
reproductive tissues, and discusses the evidence supporting a role for
these enzymes in modulating the structure and function of reproductive
organs.
REVIEW, TUTORIAL
Matrix metalloproteinases as mediators of reproductive function
Department of Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.
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C. Ma and N. Chegini Regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-{beta}1 Mol. Hum. Reprod., October 1, 1999; 5(10): 950 - 954. [Abstract] [Full Text] [PDF]
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N. Chegini, C. Ma, J. Davis, P. Duff, and C. Rosa Differential Expression of Transforming Growth Factor-{beta}1 and Transforming Growth Factor-{beta} Receptors in Myometrium of Women With Failed Induction of Labor, No Labor, and Preterm Labor Reproductive Sciences, September 1, 1999; 6(5): 258 - 263. [Abstract] [PDF]
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S. Oksjoki, S. Sallinen, E. Vuorio, and L. Anttila Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary Mol. Hum. Reprod., September 1, 1999; 5(9): 803 - 808. [Abstract] [Full Text] [PDF]
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M.-A. Ledingham, F. C. Denison, S. C. Riley, and J. E. Norman Matrix metalloproteinases-2 and -9 and their inhibitors are produced by the human uterine cervix but their secretion is not regulated by nitric oxide donors Hum. Reprod., August 1, 1999; 14(8): 2089 - 2096. [Abstract] [Full Text] [PDF]
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S. C. Riley, R. Leask, T. Chard, N. C. Wathen, A. A. Calder, and D. C. Howe Secretion of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases into the intrauterine compartments during early pregnancy Mol. Hum. Reprod., April 1, 1999; 5(4): 376 - 381. [Abstract] [Full Text] [PDF]
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M. Winkler, D.-C. Fischer, P. Ruck, T. Marx, E. Kaiserling, A. Oberpichler, H. Tschesche, and W. Rath Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment Hum. Reprod., April 1, 1999; 14(4): 1096 - 1100. [Abstract] [Full Text] [PDF]
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L.V. Bogic, R.H. Ohira, S.Y. Yamamoto, K.J. Okazaki, K. Millar, and G.D. Bryant-Greenwood Tissue Plasminogen Activator and Its Receptor in the Human Amnion, Chorion, and Decidua at Preterm and Term Biol Reprod, April 1, 1999; 60(4): 1006 - 1012. [Abstract] [Full Text]
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C.F. Singer, E. Marbaix, P. Lemoine, Y. Eeckhout, and P.J. Courtoy Interleukin-1 receptor-ligand interactions modulate interstitial collagenase-1 production by human endometrial fibroblasts Mol. Hum. Reprod., March 1, 1999; 5(3): 240 - 245. [Abstract] [Full Text] [PDF]
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J. L. Skinner, S. C. Riley, A. E. Gebbie, A. F. Glasier, and H. O.D. Critchley Regulation of matrix metalloproteinase-9 in endometrium during the menstrual cycle and following administration of intrauterine levonorgestrel Hum. Reprod., March 1, 1999; 14(3): 793 - 799. [Abstract] [Full Text] [PDF]
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 G. Velasco, A. M. Pendas, A. Fueyo, V. Knauper, G. Murphy, and C. Lopez-Otin Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members J. Biol. Chem., February 19, 1999; 274(8): 4570 - 4576. [Abstract] [Full Text] [PDF]
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W. Tschugguel, C. Schneeberger, G. Unfried, G. Brautigam, F. Stonek, F. Wieser, E. Vytiska-Binstorfer, K. Czerwenka, W. Weninger, A. Kaider, et al. Elevation of Inducible Nitric Oxide Synthase Activity in Human Endometrium during Menstruation Biol Reprod, February 1, 1999; 60(2): 297 - 304. [Abstract] [Full Text] [PDF]
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H. Lei, E. E. Furth, R. Kalluri, P. Wakenell, C. B. Kallen, J. J. Jeffrey, P. S. Leboy, and J. F. Strauss III Induction of Matrix Metalloproteinases and Collagenolysis in Chick Embryonic Membranes before Hatching Biol Reprod, January 1, 1999; 60(1): 183 - 189. [Abstract] [Full Text]
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L. A. Rudolph-Owen, O. D. Slayden, L. M. Matrisian, and R. M. Brenner Matrix Metalloproteinase Expression in Macaca mulatta Endometrium: Evidence for Zone-Specific Regulatory Tissue Gradients Biol Reprod, December 1, 1998; 59(6): 1349 - 1359. [Abstract] [Full Text]
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W. C. Duncan, A. S. McNeilly, and P. J. Illingworth The Effect of Luteal "Rescue" on the Expression and Localization of Matrix Metalloproteinases and Their Tissue Inhibitors in the Human Corpus Luteum J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2470 - 2478. [Abstract] [Full Text]
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 L. A. Rudolph-Owen, P. Cannon, and L. M. Matrisian Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility Mol. Biol. Cell, February 1, 1998; 9(2): 421 - 435. [Abstract] [Full Text]
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L. A. Rudolph-Owen, D. L. Hulboy, C. L. Wilson, J. Mudgett, and L. M. Matrisian Coordinate Expression of Matrix Metalloproteinase Family Members in the Uterus of Normal, Matrilysin-Deficient, and Stromelysin-1-Deficient Mice Endocrinology, November 1, 1997; 138(11): 4902 - 4911. [Abstract] [Full Text] [PDF]
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 C. F. Singer, E. Marbaix, I. Kokorine, P. Lemoine, J. Donnez, Y. Eeckhout, and P. J. Courtoy Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual block by ovarian steroids PNAS, September 16, 1997; 94(19): 10341 - 10345. [Abstract] [Full Text] [PDF]
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