Molecular Human Reproduction, Vol 3, 1113-1117, Copyright © 1997 by Oxford University Press
L Sahlin, Y Stjernholm, A Holmgren, G Ekman and H Eriksson
The classic function for thioredoxin is to act as a hydrogen donor for the
enzyme ribonucleotide reductase, which is essential for DNA synthesis. In
addition, thioredoxin participates in the regulation of different metabolic
processes via thiol redox control. These kind of processes involve changes
in the activity of different enzymes, receptors or transcription factors
via dithiol/disulphide interchange reactions. Thioredoxin is present in the
human decidua and trophoblasts. This study was performed to investigate
whether thioredoxin mRNA is present in the human cervix, and differently
expressed during pregnancy as compared with the non-pregnant state.
Cervical biopsies and serum samples were obtained from 28 late pregnant, 41
post-partum and 15 non-pregnant menstruating women. The tissues were
analysed for thioredoxin mRNA content using a solution hybridization
technique. The thioredoxin mRNA level increased 3-fold at late pregnancy in
comparison with the non-pregnant state. No further increase was seen
immediately after parturition, either after spontaneous delivery or after
pharmacological induction. There was a positive correlation between the
cervical thioredoxin mRNA level and the serum oestradiol concentration in
the non-pregnant group. We suggest that thioredoxin mRNA in the human
cervix is regulated, at least partly, by oestradiol.
JOURNAL ARTICLE
The expression of thioredoxin mRNA is increased in the human cervix during pregnancy
Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Umekawa, T. Sugiyama, T. Kihira, N. Murabayashi, L. Zhang, K. Nagao, Y. Kamimoto, N. Ma, J. Yodoi, and N. Sagawa Overexpression of Thioredoxin-1 Reduces Oxidative Stress in the Placenta of Transgenic Mice and Promotes Fetal Growth via Glucose Metabolism Endocrinology, August 1, 2008; 149(8): 3980 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Stygar, B. Masironi, H. Eriksson, and L. Sahlin Studies on estrogen receptor (ER) {alpha} and {beta} responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists J. Endocrinol., July 1, 2007; 194(1): 101 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stavreus-Evers, B. Masironi, B.-M. Landgren, A. Holmgren, H. Eriksson, and L. Sahlin Immunohistochemical localization of glutaredoxin and thioredoxin in human endometrium: a possible association with pinopodes Mol. Hum. Reprod., June 1, 2002; 8(6): 546 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sahlin, H. Wang, Y. Stjernholm, M. Lundberg, G. Ekman, A. Holmgren, and H. Eriksson The expression of glutaredoxin is increased in the human cervix in term pregnancy and immediately post-partum, particularly after prostaglandin-induced delivery Mol. Hum. Reprod., December 1, 2000; 6(12): 1147 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sahlin, H. Wang, B. Lindblom, H. Eriksson, A. Holmgren, and A. Blanck Thioredoxin expression in human myometrium and fibroids Mol. Hum. Reprod., January 1, 2000; 6(1): 60 - 67. [Abstract] [Full Text] [PDF]
|
|