Molecular Human Reproduction, Vol 3, 501-505, Copyright © 1997 by Oxford University Press
MS Patankar, K Ozgur, S Oehninger, A Dell, H Morris, M Seppala and GF Clark
Protection of the gametes from potential immune responses is a primary
function in human reproduction. The primary cell type responsible for the
innate immune response in the uterus is the natural killer (NK) cell. NK
cells normally recognize Class I major histocompatibility (MHC) molecules
on potential target cells. Since both human spermatozoa and human oocytes
do not express Class I MHC molecules on their surfaces, the appropriate
cell surface signal that abrogates potential NK cell-mediated responses
directed against these gametes is unknown. Recent evidence indicates that
surface expression of bisecting-type N- linked glycans protects cells
sensitive to NK cell-mediated lysis. We report that the zona pellucida of
the human egg and plasma membranes of human spermatozoa potentially bind a
lectin probe specific for bisecting type glycans in a
carbohydrate-dependent manner. Since the innate immune response in the
uterus is primarily mediated by NK cells, our results indicate that human
gametes may be protected from this response by expressing bisecting type
N-linked glycans on their surfaces.
JOURNAL ARTICLE
Expression of glycans linked to natural killer cell inhibition on the human zona pellucida
Department of Biochemistry, Eastern Virginia Medical School, Norfolk 23501, USA.
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