Molecular Human Reproduction, Vol 3, 713-723, Copyright © 1997 by Oxford University Press
SF Bjorn, N Hastrup, LR Lund, K Dano, JF Larsen and C Pyke
The spatial expression of mRNA for matrix metalloproteinase 2 (MMP-2), its
putative activator, the membrane-type 1 matrix metalloproteinase (MT1-MMP),
and the MMP-2 substrate type IV collagen was investigated in human
placentas of both normal and tubal ectopic pregnancies and in cyclic
endometrium using in-situ hybridization. Cytokeratin staining applied to
adjacent sections was used to identify epithelial and trophoblast cells. In
both normal and tubal pregnancies MT1-MMP, MMP-2 and type IV collagen mRNA
were highly expressed and co-localized in the extravillous cytotrophoblasts
of anchoring villi, in cytotrophoblasts that had penatrated into the
placental bed and in cytotrophoblastic cell islands. In addition, the
decidual cells of normal pregnancies in some areas co-expressed MT1-MMP and
MMP-2 mRNA, with moderate signals for both components. Fibroblast-like
stromal cells in tubal pregnancies were positive for MMP-2 mRNA but
generally negative for MT1-MMP mRNA. The consistent co-localization of
MT1-MMP with MMP-2 and type IV collagen in the same subset of
cytotrophoblasts strongly suggests that all three components co-operate in
the tightly regulated fetal invasion process. The co-expression of MT1-MMP
and MMP-2 mRNA in some of the decidual cells indicates that these cells are
also actively involved in the placentation process.
JOURNAL ARTICLE
Co-ordinated expression of MMP-2 and its putative activator, MT1-MMP, in human placentation
Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.
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