Molecular Human Reproduction, Vol 4, 77-81, Copyright © 1998 by Oxford University Press
KJ Lim, OA Odukoya, RA Ajjan, TC Li, AP Weetman and ID Cooke
The human embryo and subsequent fetus is a semi-allograft and
immunologically foreign to the mother. Successful embryonic implantation
and maintenance of normal pregnancy depends on intricate interactions
between the invading embryo, maternal endometrium and maternal immune
response. Cytokines are pivotal in determining the type of maternal
T-helper immune response, which can be divided into T- helper 1
(TH1)-mediated delayed hypersensitivity and T-helper 2 (TH2)- mediated
humoral immunity. We examined the pattern of TH1 [interleukin (IL)-2, IL-12
and interferon-gamma] and TH2 (IL-4 and IL-6) cytokine expression in the
peri-implantation endometrium of 10 fertile, multiparous women. Endometrial
samples were timed to the mid-cycle luteinizing hormone (LH) surge, with
collection on days LH+7 to LH+9. Analysis for cytokine mRNA was by mRNA
extraction and reverse transcription-polymerase chain reaction. The results
show a lack of TH1 and predominant TH2 cytokine expression. We postulate
that endometrial cytokines may contribute to the local modulation of
maternal adaptive immune response in peri-implantation endometrium, to
facilitate successful embryonic implantation and maintenance of pregnancy.
JOURNAL ARTICLE
Profile of cytokine mRNA expression in peri-implantation human endometrium
Sheffield University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, UK.
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