Molecular Human Reproduction, Vol 4, 87-91, Copyright © 1998 by Oxford University Press
K Kokawa, T Shikone and R Nakano
To investigate possible effects of implantation on apoptosis, we examined
the cleavage of DNA in human chorionic villi and decidua in intrauterine
and ectopic pregnancy. Very limited but detectable cleavage of DNA was
recognized in the chorionic villi and decidua in normal pregnancy. A ladder
pattern, characteristic of the apoptotic breakdown of DNA, was present in
the villi in tubal pregnancy. High molecular weight DNA was predominant in
the decidua in tubal pregnancy. Quantitative analysis of low molecular
weight fragments of DNA revealed a significant increase in the villous
tissue, together with a significant decrease in the decidual tissue, in
tubal pregnancy as compared to those in normal pregnancy. An analysis in
situ revealed that apoptotic cells were predominant in the
syncytiotrophoblast in tubal pregnancy. In decidual tissue, labelled cells
were occasionally seen in normal pregnancy, and their numbers decreased in
tubal pregnancy. The present study demonstrates that apoptosis occurs in
the villi, but not in the decidua in tubal pregnancy, unlike the situation
in normal pregnancy. Our results suggest that the implantation site might
affect the occurrence of apoptotic changes in early pregnancy of humans.
JOURNAL ARTICLE
Apoptosis in human chorionic villi and decidua in normal and ectopic pregnancy
Department of Obstetrics and Gynaecology, Wakayama Medical College, Japan.
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