Molecular Human Reproduction, Vol 4, 946-950, Copyright © 1998 by Oxford University Press
A Moriyama, K Shimoya, A Kawamoto, K Hashimoto, I Ogata, I Kunishige, K Ohashi, C Azuma, F Saji and Y Murata
In this study, we quantified secretory leukocyte protease inhibitor (SLPI)
and elastase in ejaculates from normal donors and infertile patients with
or without leukospermia and investigated the effect of SLPI on sperm
motility reduced by elastase. Western blot analysis revealed that SLPI
protein was detected in the seminal plasma. The SLPI titre in the seminal
plasma with leukospermia was lower than that in the seminal plasma without
leukospermia and in the seminal plasma of fertile donors. The elastase
concentration in the seminal plasma with leukospermia was significantly
higher than that in the seminal plasma without leukospermia. A significant
correlation between SLPI and elastase concentrations in the seminal plasma
(r = 0.36, P< 0.01) was observed. There was a positive correlation
between SLPI titre in the seminal plasma and sperm motility (r = 0.51, P
< 0.001). SLPI recovered the sperm motility reduced by elastase in a
dose-dependent manner. Our results suggest that SLPI is a potential
substance to treat infertile patients with leukospermia.
JOURNAL ARTICLE
Secretory leukocyte protease inhibitor (SLP) concentrations in seminal plasma: SLPI restores sperm motility reduced by elastase
Department of Obstetrics and Gynecology, Faculty of Medicine, Osaka University, Suita City, Japan.
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