Molecular Human Reproduction, Vol 4, 1150-1156, Copyright © 1998 by Oxford University Press
P Vigano, B Gaffuri, E Somigliana, M Busacca, AM Di Blasio and M Vignali
The relationship between the immune and the endometrial systems has been
recently suggested to be critical to the development of endometriosis. We
previously showed that one of the molecules involved in the complex events
that allow this interaction is the adhesion molecule intercellular adhesion
molecule (ICAM)-1. This study was designed to evaluate whether differences
in ICAM-1 mRNA and protein expression might exist between eutopic
endometrial cells and ectopic cells derived from endometriomas. Stromal
cells were dispersed from samples of endometrium and ovarian endometriomas
biopsied synchronously from 24 patients with endometriosis. We established
that the relative expression of ICAM transcript was significantly higher in
ectopic cells than that found in cultures derived from endometrial samples.
Moreover, ectopic cells demonstrated a significant overexpression of ICAM-1
protein in both its cell-bound and soluble form (sICAM-1) (P < 0.05).
Interestingly, endometrial secretion of sICAM-1 was shown to vary during
the menstrual cycle as proliferative phase samples released significantly
higher concentrations of the soluble protein compared to the secretory
phase. In contrast, this cycle-dependent pattern was absent in stromal
cells derived from endometriomas. Moreover, interleukin (IL-1beta) was able
to increase sICAM-1 shedding from endometrial cells in a
concentration-dependent manner and this IL-1beta- mediated induction could
be slightly enhanced by oestradiol. As sICAM-1 is able to interfere with
ICAM-1-mediated immune functions, the release of higher concentrations from
ectopic samples may be the mechanism by which ectopic endometrial cells
escape immunosurveillance.
JOURNAL ARTICLE
Expression of intercellular adhesion molecule (ICAM)-1 mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture
II Department of Obstetrics and Gynecology, Clinica L. Mangiagalli, University of Milano, Italy.
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