Molecular Human Reproduction, Vol 4, 1157-1164, Copyright © 1998 by Oxford University Press
T Toki, A Mori, M Shimizu, T Nikaido and S Fujii
The aim of the present study was to gain a better understanding of the
localization of apoptotic cells within the human endometrium during the
menstrual cycle and to elucidate the relationships among the following for
the human endometrium: apoptosis, p21 expression, and cell proliferation.
Apoptosis and p21 expression were identified mainly in the glandular cells
of the basal layer in the late secretory phase. In contrast, cells positive
for Ki-67 were observed predominantly in the functional layer (in the
proliferative phase in glandular cells and in the secretory phase in
stromal cells). A very strong positive correlation (r = 0.81; P < 0.001)
was demonstrated between the number of apoptotic cells and the number of
p21-positive cells present among the glandular cells but, topographically,
individual apoptotic cells were not coincident with p21-positive cells in
serial sections. The results of this study suggest that the proliferation
of the glandular cells of the basal layer is regulated by both apoptosis
and p21 expression, particularly in the late secretory phase. Such
regulation may be necessary to maintain a healthy population of glandular
cells in the basal layer of the endometrium.
JOURNAL ARTICLE
Localization of apoptotic cells within the human endometrium and correlation between apoptosis and p21 expression
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
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