Molecular Human Reproduction, Vol 4, 453-471, Copyright © 1998 by Oxford University Press
S Benoff
Recent advances in characterizing sperm surface receptors and ion channels,
when combined with the rapidly expanding knowledge of interactions among
second messenger systems in somatic cells, permit formulation of a
tentative molecular mechanism for the regulation of the human sperm
acrosome reaction. As spermatozoa pass through the cumulus mass,
progesterone binds to its sperm surface receptor, alkalinizes the sperm
head cytosol and potentiates changes in intracellular ionized calcium.
Primary binding of spermatozoa to egg involves receptors for mannosyl,
N-acetylglucosaminyl and, possibly, fucosyl residues of the glycosylated
zona protein, ZP3. These receptors aggregate on multivalent ligand binding,
migrate to the equatorial region along an actin filament network formed
between the plasma and acrosomal membranes during capacitation, and
activate a G protein/protein kinase A/protein kinase C second messenger
system and a secondary proteolysis signal. Binding of a receptor tyrosine
kinase to ZP3 amino acid residues simultaneous with the sugar recognition
event triggers tyrosine phosphorylation signalling. All signals combine to
open a voltage-dependent calcium channel. The resulting elevated calcium
signal depolymerizes the inter-membrane actin network and activates
phospholipases, leading to an acrosome reaction.
REVIEW, ACADEMIC
Modelling human sperm-egg interactions in vitro: signal transduction pathways regulating the acrosome reaction
Department of Obstetrics and Gynecology, North Shore University Hospital-New York University Medical College, Manhasset 11030, USA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Escalier Knockout mouse models of sperm flagellum anomalies Hum. Reprod. Update, July 1, 2006; 12(4): 449 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Ashizawa, G J Wishart, S Katayama, D Takano, A R A H Ranasinghe, K Narumi, and Y Tsuzuki Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A. Reproduction, June 1, 2006; 131(6): 1017 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Ashizawa, G J Wishart, S Katayama, D Takano, M Maeda, E Arakawa, and Y Tsuzuki Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro Reproduction, January 1, 2006; 131(1): 71 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Ashizawa, G J Wishart, A R A H Ranasinghe, S Katayama, and Y Tsuzuki Protein phosphatase-type 2B is involved in the regulation of the acrosome reaction but not in the temperature-dependent flagellar movement of fowl spermatozoa Reproduction, December 1, 2004; 128(6): 783 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Delle Monache, F. Flori, C. Della Giovampaola, A. Capone, G.B. La Sala, F. Rosati, R. Colonna, C. Tatone, and R. Focarelli Gp273, the Ligand Molecule for Sperm-Egg Interaction in the Bivalve Mollusk, Unio elongatulus, Binds to and Induces Acrosome Reaction in Human Spermatozoa Through a Protein Kinase C-Dependent Pathway Biol Reprod, December 1, 2003; 69(6): 1779 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nayernia, F. Vauti, A. Meinhardt, C. Cadenas, S. Schweyer, B. I. Meyer, I. Schwandt, K. Chowdhury, W. Engel, and H.-H. Arnold Inactivation of a Testis-specific Lis1 Transcript in Mice Prevents Spermatid Differentiation and Causes Male Infertility J. Biol. Chem., November 28, 2003; 278(48): 48377 - 48385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yan, A. H. Assadi, A. Wynshaw-Boris, G. Eichele, M. M. Matzuk, and G. D. Clark Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis PNAS, June 10, 2003; 100(12): 7189 - 7194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Tollner, A. I. Yudin, G. N. Cherr, and J. W. Overstreet Real-Time Observations of Individual Macaque Sperm Undergoing Tight Binding and the Acrosome Reaction on the Zona Pellucida Biol Reprod, February 1, 2003; 68(2): 664 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Revelli, D. Ghigo, F. Moffa, M. Massobrio, and I. Tur-Kaspa Guanylate Cyclase Activity and Sperm Function Endocr. Rev., August 1, 2002; 23(4): 484 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Grace, R. A. Bronson, and B. Ghebrehiwet Surface Expression of Complement Receptor gC1q-R/p33 Is Increased on the Plasma Membrane of Human Spermatozoa after Capacitation Biol Reprod, March 1, 2002; 66(3): 823 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Revelli, C. Costamagna, F. Moffa, E. Aldieri, S. Ochetti, A. Bosia, M. Massobrio, B. Lindblom, and D. Ghigo Signaling Pathway of Nitric Oxide-Induced Acrosome Reaction in Human Spermatozoa Biol Reprod, June 1, 2001; 64(6): 1708 - 1712. [Abstract] [Full Text]
|
|
|
|
 |
|
 W.-Y. Son, J.-H. Lee, J.-H. Lee, and C.-T. Han Acrosome reaction of human spermatozoa is mainly mediated by {alpha}1H T-type calcium channels Mol. Hum. Reprod., October 1, 2000; 6(10): 893 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Morales, E. Pizarro, M. Kong, B. Kerr, F. Ceric, and P. Vigil Gonadotropin-Releasing Hormone-Stimulated Sperm Binding to the Human Zona Is Mediated by a Calcium Influx Biol Reprod, August 1, 2000; 63(2): 635 - 642. [Abstract] [Full Text]
|
|
|
|
|
|
L. O. Goodwin, D. S. Karabinus, and R. G. Pergolizzi Presence of N-cadherin transcripts in mature spermatozoa Mol. Hum. Reprod., June 1, 2000; 6(6): 487 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jacob, I. R. Hurley, L. O. Goodwin, G. W. Cooper, and S. Benoff Molecular characterization of a voltage-gated potassium channel expressed in rat testis Mol. Hum. Reprod., April 1, 2000; 6(4): 303 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. O. Goodwin, D. S. Karabinus, R. G. Pergolizzi, and S. Benoff L-type voltage-dependent calcium channel {alpha}-1C subunit mRNA is present in ejaculated human spermatozoa Mol. Hum. Reprod., February 1, 2000; 6(2): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.L. Hortas, J.A. Castilla, M.T. Gil, J. Molina, M.L. Garrido, M. Morell, and M. Redondo Decreased sperm function of patients with myotonic muscular dystrophy Hum. Reprod., February 1, 2000; 15(2): 445 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Karhumaa, S. Parkkila, O. Tureci, A. Waheed, J.H. Grubb, G. Shah, A.-K. Parkkila, K. Kaunisto, J. Tapanainen, W.S. Sly, et al. Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium Mol. Hum. Reprod., January 1, 2000; 6(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cai, Y. Maeda, A. Cedzich, V. E. Torres, G. Wu, T. Hayashi, T. Mochizuki, J. H. Park, R. Witzgall, and S. Somlo Identification and Characterization of Polycystin-2, the PKD2 Gene Product J. Biol. Chem., October 1, 1999; 274(40): 28557 - 28565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Bauskin, D. R. Franken, U. Eberspaecher, and P. Donner Characterization of human zona pellucida glycoproteins Mol. Hum. Reprod., June 1, 1999; 5(6): 534 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.J. Publicover and C.L.R. Barratt Voltage-operated Ca2+ channels and the acrosome reaction: which channels are present and what do they do? Hum. Reprod., April 1, 1999; 14(4): 873 - 879. [Abstract] [Full Text] [PDF]
|
|