Molecular Human Reproduction, Vol 4, 477-481, Copyright © 1998 by Oxford University Press
S Quenby, C Brazeau, A Drakeley, DI Lewis-Jones and G Vince
Tumour suppressor genes may have a role in the control of trophoblast cell
population expansion as trophoblast invasion occurs. To investigate this
hypothesis, the location of tumour suppressor gene and proto-oncogene
products were studied at various stages of trophoblast differentiation and
invasion. Trophoblast and decidua were obtained from eight women having a
therapeutic termination of pregnancy. Immunohistochemistry was used to
localize the products of c-myc, c-erB- 2, RB, BCL-2, P21, and P53 genes and
anti-cytokeratin was used to identify fetal cells amongst the maternal
decidual cells. The most differentiated and furthest invading trophoblast
cell type, the multinucleated trophoblast, expressed a combination of genes
which may indicate a high apoptotic rate. The other fully differentiated
trophoblast, the syncytiotrophoblast, expressed BCL-2 suggesting protection
from apoptosis. The co-occurrence of proto-oncogenes and the products of
tumour suppressor genes in first trimester trophoblast suggests an
important role not only in negative regulation of cellular invasion but
also in population expansion through the presence of oncogenes and
anti-apoptotic proteins.
JOURNAL ARTICLE
Oncogene and tumour suppressor gene products during trophoblast differentiation in the first trimester
Department of Obstetrics and Gynaecology, University of Liverpool, UK.
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