Molecular Human Reproduction, Vol 4, 491-495, Copyright © 1998 by Oxford University Press
L Marions, K Gemzell Danielsson and M Bygdeman
Integrins are cell surface receptors for the extracellular matrix and
connect extracellular cell adhesion proteins to cytoskeletal components.
Several investigators have recently described the expression of different
integrins in the human endometrium as markers of receptivity. In the
present study we investigated the effect of various doses of the
antiprogestin mifepristone on the endometrial expression of integrins
during the implantation phase. Endometrial biopsies from healthy fertile
women were obtained in the midluteal phase. The study included one control
and one, two or three treatment cycles. In treatment cycles either 2.5 (n =
9) or 5 mg (n = 5) of mifepristone was administered once weekly, 0.5 mg
daily (n = 5), or 200 mg as a single dose administered on day 2 after the
luteinizing hormone surge (day LH + 2; n = 8). By using polyclonal
antibodies against integrin alpha(v)beta3, subunit beta3 and subunit alpha4
we found reduced immunostaining for alpha4 and beta3 subunit in glandular
epithelium after treatment with mifepristone while alpha(v)beta3,
expression appeared to be unaffected. No differences between treatment
groups were noted. This study demonstrates that treatment with mifepristone
interferes with integrin distribution during the implantation window. This
may imply that the contraceptive effect of mifepristone is primarily due to
impaired endometrial receptivity. However, since no effect was shown on the
distribution of the vitronectin receptor, this integrin might be regulated
differently by other factors such as cytokines.
JOURNAL ARTICLE
The effect of antiprogestin on integrin expression in human endometrium: an immunohistochemical study
Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
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