Molecular Human Reproduction, Vol 4, 509-513, Copyright © 1998 by Oxford University Press
J Fujimoto, S Ichigo, H Sakaguchi, R Hirose and T Tamaya
Steroid hormones, e.g. progesterone and oestradiol, may be responsible for
the production and expression of a variety of angiogenic growth factors
present in endometrial tissue. The expression of platelet- derived
endothelial cell growth factor (PD-ECGF) in neovascularization after
regression of the microvessels in the endometrium was examined. PD-ECGF
protein expression in the endometrium during the menstrual cycle was
determined by a sandwich enzyme immunoassay. Transcription levels of
PD-ECGF were measured by a quantitative reverse transcription- polymerase
chain reaction (RT-PCR) Southern blot technique. The data show that levels
of PD-ECGF protein and mRNA in uterine endometrium did not alter during the
proliferative phase prior to ovulation. During the midcycle phase a sharp
transient fall in mRNA levels accompanied by a gradual drop in protein
levels was observed. After ovulation transcription of PD-ECGF recovered
with a sharp increase in mRNA levels which persisted during the ovulatory
phase. PD-ECGF protein levels were temporarily low after ovulation, but
increased remarkably through the late secretory phase. PD-ECGF expression
in the endometrium seems to be inversely correlated with oestradiol
concentrations during the menstrual cycle.
JOURNAL ARTICLE
Expression of platelet-derived endothelial cell growth factor and its mRNA in uterine endometrium during the menstrual cycle
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
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