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Molecular Human Reproduction, Vol. 5, No. 1, 14-16, January 1999
© 1999 European Society of Human Reproduction and Embryology

CAG repeat length in the androgen receptor gene of infertile Japanese males with oligozoospermia

Shinji Komori1, Hiroyuki Kasumi1, Ri-ichiro Kanazawa1, Kazuko Sakata1, Yuko Nakata1, Hiroshi Kato2 and Koji Koyama1,3

1 Department of Obstetrics and Gynecology, Hyogo College of Medicine,1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8131, and 2 Advance Fertility Center, Huchu Hospital, Hiko-cho, Izumi, Osaka, 594-0076, Japan

We analysed the CAG repeat length in exon 1 of the androgen receptor gene in 59 idiopathic Japanese infertile males with oligozoospermia; 36 fertile males were also analysed as controls. The number of CAG repeats in infertile males ranged from 14 to 32 (mean 21.2 ± 4.2), whereas the number of CAG repeats in fertile males ranged from 16 to 31 (mean 21.4 ± 3.5). Among infertile males, six possessed a short form of 14 CAG repeats and three possessed 15 CAG repeats. On the other hand, fertile males did not possess the short form of 14 or 15 CAG repeats. The incidence of infertile males with 14 and 15 CAG repeats was significantly higher (P < 0.05) than that of fertile males. Although the sample size is small, the results suggest that the reduction of CAG repeats in exon 1 of the androgen receptor is closely related to impaired spermatogenesis in infertile Japanese males.

androgen receptor/CAG repeat/oligozoospermia

3 To whom correspondence should be addressed


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