Molecular Human Reproduction, Vol. 5, No. 1, 17-21,
January 1999
© 1999 European Society of Human Reproduction and Embryology
Expression of oestrogen receptor 
and ß mRNA in corpus luteum of human subjects
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, 40 Tsukasamachi, Gifu 500-8705, Japan
To investigate the role of oestrogen receptor ß (ERß) in the function of human ovarian corpus luteum, the levels of luteal ER
and ERß mRNA were determined using competitive reverse transcription–polymerase chain reaction-Southern blot analysis. The expression of ER and ERß mRNA was detected in all luteal samples analysed. Luteal ER and ERß mRNA levels were significantly lower (P < 0.01 and P < 0.05 respectively) at the late secretory phase than those at the early and mid-secretory phases of the endometrium. The ratio of ER to ERß mRNA levels showed no change during the secretory phase of the endometrium. This study demonstrates that ERß is co-expressed with ER in human corpus luteum and is likely to play a biological role in the regulation of steroidal action of the corpus luteum with ER.
ER/ERß/human corpus luteum/mRNA
1 To whom correspondence should be addressed
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