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Molecular Human Reproduction, Vol. 5, No. 1, 79-83, January 1999
© 1999 European Society of Human Reproduction and Embryology

Endometrial lysosomal enzyme activity in normal cycling endometrium

Iris Y. Wang1, Freddie J. Cornillie2, Susan Barsamian3, Debra Street4, Frank Manconi1 and Ian S. Fraser1,5

1 Sydney Centre for Reproductive Health Research, Department of Obstetrics & Gynaecology, University of Sydney, NSW 2006, 2 Department of Obstetrics and Gynaecology, Catholieke Universiteit Leuven, Herestraat 49, B3000 Leuven, Belgium, 3 Sydney Centre for Reproductive Health Research, Department of Obstetrics & Gynaecology, University of Sydney, 4 Dept. Mathematical Sciences, University of Technology, Sydney, Australia

The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-ß-D-glucosaminidase, {alpha}-L-fucosidase and {alpha}-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-ß-D-glucosaminidase was relatively high, whilst that of {alpha}-L-fucosidase and {alpha}-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle.

acid phosphatase/dysfunctional uterine bleeding/lysosomal enzymes/menorrhagia

5 To whom correspondence should be addressed


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I. Y. Wang, I. S. Fraser, S. P. Barsamian, F. Manconi, D. J. Street, F. J. Cornillie, and P. Russell
Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women
Mol. Hum. Reprod., March 1, 2000; 6(3): 258 - 263.
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