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Molecular Human Reproduction, Vol. 5, No. 1, 84-87, January 1999
© 1999 European Society of Human Reproduction and Embryology

The CTLA-4 gene is expressed in placental fibroblasts

K.A. Kaufman1, J.A. Bowen2, A.F. Tsai1, J.A. Bluestone3, J.S. Hunt2 and C. Ober1,4

1 Department of Human Genetics, The University of Chicago, 924 E. 57th Street, Chicago, IL 60637, 2 Department of Anatomy and Cell Biology, Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7400, and 3 Ben May Institute for Cancer Research and Department of Pathology, The University of Chicago, 5841 S.Maryland Avenue, Chicago, IL 60637, USA

In order to elucidate the mechanisms that ensure survival of the allogeneic fetus, we are investigating the expression pattern of genes that are involved in peripheral self-tolerance in tissues at the maternal–fetal interface. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a negative regulator of T cell activation and may modulate peripheral self-tolerance. Previously, we reported the preferential transmission of maternally-inherited shorter alleles at a 3'-UTR microsatellite locus to liveborn children, but random transmission of paternally-inherited alleles, suggesting that CTLA-4 may be involved in the maintenance of tolerance at the maternal–fetal interface. In this report, we demonstrate that CTLA-4 mRNA and protein are indeed expressed in fetal tissues at the maternal–fetal interface throughout gestation.

CTLA-4/fibroblasts/immunochemistry/maternal–fetal interface/peripheral self tolerance

4 To whom correspondence should be addressed


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