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Molecular Human Reproduction, Vol. 5, No. 12, 1127-1134, December 1999
© 1999 European Society of Human Reproduction and Embryology

Molecular aspects of spermatogenesis

Identification, sequence analysis and expression of transcripts encoding a putative metalloproteinase, eMDC II, in human and macaque epididymis

Jenny A. Jury, Anthony C.F. Perry and Len Hall1

Department of Biochemistry, University of Bristol, School of Medical Sciences, Bristol, BS8 1TD, UK

Abstract

The metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) family is a large group of sequence-related proteins, first characterized in the male reproductive tract, but subsequently also identified in non-reproductive tissues. Their primary translation products are of ~90 kDa and each can be divided into distinct domains which show remarkable homology to reprolysins; snake venom haemorrhagic components possessing metalloproteinase and/or disintegrin domains. Several MDC proteins are abundantly-expressed in the male reproductive tract, suggesting functions in fertility. We now describe the cloning, sequence determination and characterization of transcripts encoding the human and macaque (Macaca fascicularis) orthologues of a novel member of the MDC family (eMDC II) which is abundantly-expressed in the epididymis. Unlike many MDC proteins expressed in the reproductive tract, eMDC II possesses the extended `catalytic centre' consensus sequence characteristic of a reprolysin-like metalloproteinase. This suggests that eMDC II has proteolytic activity.

cysteine-rich protein/disintegrin-like/epididymis/metalloproteinase/metalloproteinase-like

Notes

1 To whom correspondence should be addressed


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