Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hennig, Y.
Right arrow Articles by Bullerdiek, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hennig, Y.
Right arrow Articles by Bullerdiek, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Human Reproduction, Vol. 5, No. 12, 1150-1154, December 1999
© 1999 European Society of Human Reproduction and Embryology

Molecular events in the uterus

Chromosomal translocations affecting 12q14–15 but not deletions of the long arm of chromosome 7 associated with a growth advantage of uterine smooth muscle cells

Yvonne Hennig1, Ulrich Deichert2, Ulrich Bonk3, Brita Thode4, Sabine Bartnitzke1 and Jörn Bullerdiek1,5

1 Center of Human Genetics and Genetic Counselling, University of Bremen, Leobener Str. ZHG, D-28359 Bremen, 2 Women's Clinic, Central Hospital St Jürgen Strasse, Bremen, 3 Institute for Pathology, Central Hospital Bremen-Nord, Bremen, 4 Institute for Pathology, Central Hospital St Jürgen Strasse, Bremen, Germany

Abstract

Cytogenetically, uterine leiomyomata are the best investigated human tumours. The most frequent clonal abnormalities are structural rearrangements involving 12q14–15 and deletions of part of the long arm of chromosome 7. The present study investigated a possible growth advantage conferred by these abnormalities, when compared with myomata having an apparently normal karyotype. A total of 155 myomata were included in the study. All samples were obtained after hysterectomy enabling karyotype analysis of all detectable tumours. Myomata with clonal chromosome abnormalities were significantly larger than those with a normal karyotype (6.8 ± 5.3 versus 3.4 ± 2.1 cm; P < 0.001). However, when differentiating between the two main aberrations, this was found to be true for the myomata with 12q14–15 changes affecting the high mobility group protein IC (HMGIC) gene (8.9 ± 5.6 cm), but not for the group of tumours characterized by deletions of chromosome 7 (3.5 ± 2.0 cm). The results are compatible with the hypothesis that myomata develop due to an unknown event, whereas the chromosomal abnormalities act as secondary changes, with those affecting the HMGIC gene increasing the growth potential of the corresponding tumours.

cytogenetics/HMGIC/leiomyomata/myoma size

Notes

5 To whom correspondence should be addressed


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
Y. Peng, J. Laser, G. Shi, K. Mittal, J. Melamed, P. Lee, and J.-J. Wei
Antiproliferative Effects by Let-7 Repression of High-Mobility Group A2 in Uterine Leiomyoma
Mol. Cancer Res., April 1, 2008; 6(4): 663 - 673.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.