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Molecular Human Reproduction, Vol. 5, No. 8, 737-741, August 1999
© 1999 European Society of Human Reproduction and Embryology

Oncogenes and tumour suppressor genes in first trimester human fetal gonadal development

S.M. Quenby1,4, M.R. Gazvani2, C. Brazeau2, J. Neilson2, D.I. Lewis-Jones2 and G. Vince3

1 Division of Obstetrics and Gynaecology, City Hospital, Hucknall Road, Nottingham, NG5 1PB, 2 Department of Obstetrics and Gynaecology and 3 Department of Immunology, University of Liverpool, Liverpool L69 3BX, UK

Tumour suppressor genes and oncogenes that control proliferation and apoptosis are known to play an important role in embryogenesis, second trimester fetal oocyte loss, adult ovulation, and in adult male testicular degeneration. We have examined tumour suppressor genes, oncogenes and oestrogen receptors during first trimester human gonadal differentiation to investigate their role at this crucial phase in development. Immunohistochemistry was used to localize the gene products of Bcl-2, c-erB-2, c-myc, p53, nm23 and oestrogen receptor. As gonadal development occurred at 6–12 weeks gestation, a changing pattern of expression was observed that varied in different cell types. The oestrogen receptor was not present in oogonia, spermatogonia and supporting cells during the first trimester. This study highlights the importance of oncogenes and tumour suppressor genes in first trimester gonadal development.

cell cycle/development/gonadal/oestrogen receptors

4 To whom correspondence should be addressed


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