Molecular Human Reproduction, Vol. 5, No. 8, 742-747,
August 1999
© 1999 European Society of Human Reproduction and Embryology
Expression of oestrogen receptor-
and -ß in ovarian endometriomata
1 Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu City 500-8705, Japan
The contribution of oestrogen receptor (ER) isoforms, ER-
and ER-ß, in oestrogen-dependent development and growth of ovarian endometriomata, is unknown. Therefore, we examined the expression of ER- and ER-ß in ovarian endometriomata and normal uterine endometrium. ER- and ER-ß were shown to be dominantly expressed in the nuclei of the epithelial lining cells of ovarian endometrioma and of the glandular cells of normal uterine endometrium. ER-ß was expressed at a much lower level than ER- in the glandular cells of normal uterine endometrium, while ER-ß was expressed at a slightly lower level than ER- in the epithelial lining cells of ovarian endometrioma. In normal uterine endometrium, ER-ß mRNA was expressed at a much lower level than ER- mRNA, and the expression pattern of ER-ß mRNA during the menstrual cycle was similar to that of ER- mRNA. On the other hand, ER-ß mRNA expression was significantly higher and over a much greater range in ovarian endometriomata (P < 0.05) than in normal uterine endometrium during the menstrual cycle, while ER- mRNA expression was relatively lower and more random. Therefore, in ovarian endometriomata, oestrogen action via ER- cascades seems to be partially damaged, as the expression of ER- mRNA does not respond to endocrinological alterations during the menstrual cycle, while the relative over-expression of ER-ß might be related to a unique oestrogen-dependent growth and spreading of ovarian endometriomata.
ER-/ER-ß/ovarian endometrioma
2 To whom correspondence should be addressed
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