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Molecular Human Reproduction, Vol. 5, No. 9, 803-808, September 1999
© 1999 European Society of Human Reproduction and Embryology

Regulation of ovarian function

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary

S. Oksjoki1, S. Sallinen1, E. Vuorio1 and L. Anttila2,3

1 Department of Molecular Biology and Medical Biochemistry, and 2 Department of Obstetrics and Gynaecology, Turku University Central Hospital, University of Turku, Kiinamyllynkatu 4–6, FIN-20520 Turku, Finland

Abstract

In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective tissue matrix. We postulated that extracellular matrix (ECM) of the ovary participates actively in ovarian functions. To test this, the mRNA levels for several ECM components were determined in the mouse ovary at six distinct stages of the 4-day oestrous cycle. Northern analysis revealed statistically significant cyclic expression patterns for the mRNAs coding for type III, IV and VI collagens as well as for the small proteoglycan, biglycan, and for syndecan-1 and osteonectin. The cyclic changes observed in the mRNAs for these structural components exceeded those for matrix metalloproteinases (MMP)-2, -9 and -13, and for tissue inhibitors of matrix metalloproteinases (TIMP)-1, -2 and -3, where the changes were not statistically significant, despite their apparent role in ECM remodelling in the ovary. These observations support the hypothesis that cyclic changes in the production and degradation of ECM are part of normal ovarian function connected with follicular maturation, rupture and corpus luteum formation.

collagen/extracellular matrix/oestrous cycle/ovary/proteoglycan

Notes

3 To whom correspondence should be addressed


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